Fertil Steril:男性性高潮与射精是两回事

2015-11-05 candy 译 MedSci原创

    在这篇文章中,我们总结了目前为止关于生理性高潮和射精的文献资料,从性器官的解剖和勃起的生理角度对性高潮和射精做出简短的描述。男性生殖器的功能解剖学:男性生殖器系统包括外部和内部生殖器官和性器官,如阴茎、前列腺、附睾和睾丸。勃起生理:阴茎勃起是复杂的神经机制调节的结果,包括中枢和外周神经因子,以及分子、血管、心理和内分泌因素,这些因素之间的平衡是最终决定阴茎

在这篇文章中,我们总结了目前为止关于生理性高潮和射精的文献资料,从性器官的解剖和勃起的生理角度对性高潮和射精做出简短的描述。

男性生殖器的功能解剖学:男性生殖器系统包括外部和内部生殖器官和性器官,如阴茎、前列腺、附睾和睾丸。

勃起生理:阴茎勃起是复杂的神经机制调节的结果,包括中枢和外周神经因子,以及分子、血管、心理和内分泌因素,这些因素之间的平衡是最终决定阴茎的勃起功能。在这一节中,我们总结了一些机制。


【脑控制】大脑控制阴茎勃起,包括通过色情视觉或想法刺激。主要参与的脑部结构包括内侧视前区(MPOA)和下丘脑室旁核(PVN)。多巴胺是最重要的大脑控制勃起的神经传递素,它可能是通过催产素的刺激释放。另一种重要的神经传递素是去甲肾上腺素,它是通过α-2激动剂(育亨宾)的效应引起勃起。其他大脑神经递质不同程度上参与勃起过程,如NO、α-黑色素细胞刺激激素(a-MSH)和阿片肽。

【自主控制】副交感神经是刺激阴茎勃起的主要介质,虽然中枢抑制交感神经系统也起着作用。对于反射勃起的主要机制是骶反射弧的保存,通过触觉阴茎刺激介导勃起。

性高潮的生理:每个专业领域,如内分泌学和生理学,对于性高潮的描述都是出自于各自领域的观点,所以就目前为止还未有关于性高潮的明确定义。性高潮和射精是两个单独的生理过程,有时很难区分,比如两者的生理特征都是相似的,包括过度换气达40次/分钟、心动过速、高血压。

性高潮与强大和高度愉快的骨盆肌肉收缩有关(特别是坐骨海绵体肌和球海绵体肌),并伴随着直肠括约肌收缩和面部表情的改变。另外性高潮后伴随着PRL与催产素水平的释放和升高;然而并不完全清楚这两种激素升高的机制。目前可以通过正电子发射断层扫描,衡量各脑部区域血流的变化,确定高潮时大脑中激活的区域。性高潮的质量和强度是可变的,例如,短期快速刺激累积的性高潮快感比慢速率的刺激积累更强烈。雄激素水平较低与较弱的高潮有关,如性腺功能减退症或老年人。另外,针对提高性快感,有人建议可增加骨盆肌肉锻炼,特别是球海绵体肌和坐骨海绵体肌的肌肉,通过收缩肌肉60次/组,3组/日,共6周。通过前列腺按摩诱导性高潮被认为是不同于直接阴茎刺激,然而前列腺按摩高潮被认为要比阴茎刺激可以达到更激烈的和弥漫的刺激性高潮,但他们需要时间实践,所以并不被大多数男人青睐。

射精的生理:射精是一种生理过程,受自主神经系统严重控制。它由两个阶段组成:发射和排出。

【发射Emission】发射阶段第一步是膀胱颈关闭,预防精液逆行溢出到膀胱。其次是前列腺分泌物排出(占最终精液量10%),其中含酸性磷酸酶、柠檬酸、锌;并且还有来自输精管的精子,从前列腺尿道混入前列腺分泌物(占10%)。最后,果糖碱化最终的精液囊泡液(占最终精液量的75%–80%)。射精的过程设计多个器官,包括自主神经、交感神经、副交感神经和盆腔神经丛。其中交感神经元在射精过程中发挥主要作用。射精的发射阶段受相当大的脑控制,所以可以通过物理或视觉刺激诱发射精的发射阶段。

【排出Expulsion】排出在发射阶段后,是射精过程的高潮,此阶段精液通过尿道排出。然而排出准确的触发机制是目前仍不清楚。

射精的神经控制:射精是由神经系统控制的,包括外周神经系统、中枢神经系统和神经递质调节。

射精的内分泌调节

【催产素】男性射精后的催产素水平较正常水平(射精前10分钟的基线值)升高了20%~360%。

催产素与内皮素-1协同作用于附睾,增加附睾收缩并推动精子前进。有研究将催产素注入雄性大鼠脑室中,发现由此促进了射精并缩短射精潜伏期与射精后不应期,而这些影响在使用催产素受体拮抗剂都被抑制。尽管这些鼓舞人心的发现和一些现有证据表明鼻内催产素可以促进男性性高潮,某一双盲安慰剂对照临床研究在验证催产素对性行为的积极影响时却失败了。

【泌乳素】高泌乳素血症对男性的性欲有明显的抑制作用。

已检测到在男性性高潮后,血清PRL水平会有一个适度的增加(15 - 20纳克/毫升),这可能也有助于高潮后的不应期。一些研究人员发现在先天或后天性早泄的男人中PRL水平同样是低的,由此推测低PRL水平是早泄的原因。这需要进一步的研究来证明。

【甲状腺激素】甲状腺激素异常和射精功能障碍的关系已经有据可查。

在第一项关于甲状腺与射精功能障碍的前瞻性多中心研究中,有一半甲状腺功能亢进症患者患有早泄。在另一项Cihan等人的单中心前瞻性研究中,发现甲状腺功能亢进患者的早泄发病率高达72%,而在经过治疗后,早泄发病率降低。Waldinger MD等人也在研究中确定了TSH与射精潜伏期具有正相关性。这些研究表明筛查射精障碍患者的甲状腺激素是必要的。

【雌激素】雌二醇在射精的发射阶段中起重要的调节作用,因它参与调节附睾收缩、管腔液的重吸收、精子的浓度。

Finkelstein 等人表明E2缺乏伴随雄激素缺乏,将导致性欲减退和勃起功能下降。 
  
总之,射精是一个复杂的过程,涉及几个解剖结构和广泛的神经调节机制和激素调控。性高潮虽然与射精有关,但它们都是独特的生理过程,并不相同。这些生理过程在许多方面仍然是未知的,需要进一步的研究,以确定射精功能障碍的治疗。

原始出处:

Alwaal A, Breyer BN, Lue TF.Normal male sexual function: emphasis on orgasm and ejaculation.Fertil Steril. 2015 Nov;104(5):1051-60. 


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1653908, encodeId=317a1653908c7, content=<a href='/topic/show?id=fc0452e2878' target=_blank style='color:#2F92EE;'>#性高潮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52728, encryptionId=fc0452e2878, topicName=性高潮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56a124401173, createdName=lifangping, createdTime=Wed Dec 02 23:42:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42755, encodeId=dc4042e55b5, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151019/IMG5624E2925EB643108.jpg, createdBy=ddfd1657548, createdName=玥月, createdTime=Sat Nov 07 18:19:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440077, encodeId=ce3814400e7ba, content=<a href='/topic/show?id=1ff646e9220' target=_blank style='color:#2F92EE;'>#射精#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46792, encryptionId=1ff646e9220, topicName=射精)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b64697855, createdName=ms2694732865965676, createdTime=Sat Nov 07 13:42:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42709, encodeId=712b42e09e5, content=很有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Nov 07 01:00:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42706, encodeId=31cd42e06ce, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sat Nov 07 00:14:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42703, encodeId=48b742e03ce, content=能配个图就好了,反正机制复杂,有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c27896859, createdName=qht521531, createdTime=Fri Nov 06 23:40:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1653908, encodeId=317a1653908c7, content=<a href='/topic/show?id=fc0452e2878' target=_blank style='color:#2F92EE;'>#性高潮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52728, encryptionId=fc0452e2878, topicName=性高潮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56a124401173, createdName=lifangping, createdTime=Wed Dec 02 23:42:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42755, encodeId=dc4042e55b5, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151019/IMG5624E2925EB643108.jpg, createdBy=ddfd1657548, createdName=玥月, createdTime=Sat Nov 07 18:19:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440077, encodeId=ce3814400e7ba, content=<a href='/topic/show?id=1ff646e9220' target=_blank style='color:#2F92EE;'>#射精#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46792, encryptionId=1ff646e9220, topicName=射精)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b64697855, createdName=ms2694732865965676, createdTime=Sat Nov 07 13:42:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42709, encodeId=712b42e09e5, content=很有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Nov 07 01:00:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42706, encodeId=31cd42e06ce, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sat Nov 07 00:14:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42703, encodeId=48b742e03ce, content=能配个图就好了,反正机制复杂,有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c27896859, createdName=qht521531, createdTime=Fri Nov 06 23:40:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
    2015-11-07 玥月

    有意思

    0

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    2015-11-07 lecoo

    很有意思

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1653908, encodeId=317a1653908c7, content=<a href='/topic/show?id=fc0452e2878' target=_blank style='color:#2F92EE;'>#性高潮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52728, encryptionId=fc0452e2878, topicName=性高潮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56a124401173, createdName=lifangping, createdTime=Wed Dec 02 23:42:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42755, encodeId=dc4042e55b5, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151019/IMG5624E2925EB643108.jpg, createdBy=ddfd1657548, createdName=玥月, createdTime=Sat Nov 07 18:19:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440077, encodeId=ce3814400e7ba, content=<a href='/topic/show?id=1ff646e9220' target=_blank style='color:#2F92EE;'>#射精#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46792, encryptionId=1ff646e9220, topicName=射精)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b64697855, createdName=ms2694732865965676, createdTime=Sat Nov 07 13:42:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42709, encodeId=712b42e09e5, content=很有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Nov 07 01:00:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42706, encodeId=31cd42e06ce, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sat Nov 07 00:14:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42703, encodeId=48b742e03ce, content=能配个图就好了,反正机制复杂,有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c27896859, createdName=qht521531, createdTime=Fri Nov 06 23:40:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
    2015-11-07 sanshengshi

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1653908, encodeId=317a1653908c7, content=<a href='/topic/show?id=fc0452e2878' target=_blank style='color:#2F92EE;'>#性高潮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52728, encryptionId=fc0452e2878, topicName=性高潮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56a124401173, createdName=lifangping, createdTime=Wed Dec 02 23:42:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42755, encodeId=dc4042e55b5, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151019/IMG5624E2925EB643108.jpg, createdBy=ddfd1657548, createdName=玥月, createdTime=Sat Nov 07 18:19:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440077, encodeId=ce3814400e7ba, content=<a href='/topic/show?id=1ff646e9220' target=_blank style='color:#2F92EE;'>#射精#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46792, encryptionId=1ff646e9220, topicName=射精)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b64697855, createdName=ms2694732865965676, createdTime=Sat Nov 07 13:42:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42709, encodeId=712b42e09e5, content=很有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sat Nov 07 01:00:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42706, encodeId=31cd42e06ce, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cab51623450, createdName=sanshengshi, createdTime=Sat Nov 07 00:14:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42703, encodeId=48b742e03ce, content=能配个图就好了,反正机制复杂,有待研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c27896859, createdName=qht521531, createdTime=Fri Nov 06 23:40:00 CST 2015, time=2015-11-06, status=1, ipAttribution=)]
    2015-11-06 qht521531

    能配个图就好了,反正机制复杂,有待研究

    0