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Combretastatin A1联合阿糖胞苷治疗复发性急性髓细胞白血病成人患者中取得积极结果

2019-12-24 Allan MedSci原创

急性髓细胞白血病CombretastatinA1阿糖胞苷
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Mateon Therapeutics近日宣布，Combretastatin A1（OXi4503）联合阿糖胞苷治疗复发性急性髓细胞白血病（AML）达到了其主要终点。研究表明，在26例可评估的AML患者中，有4例完全缓解（CR / CRi）和1例部分缓解（PR）。

Mateon Therapeutics近日宣布，Combretastatin A1（OXi4503）联合阿糖胞苷治疗复发性急性髓细胞白血病（AML）达到了其主要终点。研究表明，在26例可评估的AML患者中，有4例完全缓解（CR / CRi）和1例部分缓解（PR）。CR反应与>1年的总生存时间相关。对于患有复发性AML的老年人，联合治疗显示出可控的毒性和对风险状况的潜在益处。

这项新疗法在复发难治AML中的安全性、可行性和早期临床活性值得在随机研究中进一步进行验证。该研究的结果将在即将举行的医学会议上发表，并与包括美国FDA在内的卫生当局进行讨论。


原始出处：

http://www.firstwordpharma.com/node/1689680#axzz68z4pBXnX

本文系梅斯医学（MedSci）原创编译整理，转载需授权!


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    2022-04-26 病毒猎手

    #急性髓细胞白血病##阿糖胞苷#

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    2022-04-26 病毒猎手

    #急性髓细胞白血病#

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    2020-07-15 ysjykql

    #RET#

    0

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style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-02-15 DEXTER3139

    #Stati#

    0

  5. 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style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-04-20 shenxlcyp

    #髓细胞白血病#

    0

  6. 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topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-05-17 hb2008ye

    #复发性#

    0

  7. 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createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Apr 20 18:38:00 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909798, encodeId=fec51909e9891, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun May 17 09:38:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068897, encodeId=2a77206889e2a, content=<a href='/topic/show?id=a56b16e6260' target=_blank style='color:#2F92EE;'>#Statin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-01-08 snowpeakxu

    #Statin#

    0

  8. 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topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-07-21 ms24272190615788285182

    #AST#

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794310, encodeId=3b491e9431052, content=<a href='/topic/show?id=04b316e617e' target=_blank style='color:#2F92EE;'>#Stati#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16761, encryptionId=04b316e617e, topicName=Stati)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Sat Feb 15 11:38:00 CST 2020, time=2020-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822175, encodeId=c6a318221e56f, content=<a href='/topic/show?id=b8611021308a' target=_blank style='color:#2F92EE;'>#髓细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102130, encryptionId=b8611021308a, topicName=髓细胞白血病)], attachment=null, authenticateStatus=null, 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topicList=[TopicDto(id=16762, encryptionId=a56b16e6260, topicName=Statin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 08 07:38:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712243, encodeId=91611e1224392, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jul 21 09:38:00 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783536, encodeId=9ced1e8353646, content=<a href='/topic/show?id=e67d501343' target=_blank style='color:#2F92EE;'>#Combretastatin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5013, encryptionId=e67d501343, topicName=Combretastatin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512a199, createdName=lilianxiang, createdTime=Sat Mar 14 16:38:00 CST 2020, time=2020-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468208, encodeId=49d1146820822, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Dec 26 01:38:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2020-03-14 lilianxiang

    #Combretastatin#

    0

  10. 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    2019-12-26 chengjn

    #髓细胞#

    0

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