JCLA:血细胞分布与阻塞性睡眠呼吸暂停的关系

2019-07-12 不详 网络

血细胞谱是临床实验室最常用的检测方法之一。然而,以往研究对阻塞性睡眠呼吸暂停(OSA)患者血细胞指标的分析并不全面。本研究旨在全面分析OSA患者的血常规。 研究人员对南方医院睡眠中心2013年5月至2018年2月收治的1087例男性患者进行回顾性研究。根据呼吸暂停低通气指数(AHI),患者分为4组,即对照组(AHI < 5, n = 135),轻度OSA(5≦AHI < 15,

血细胞谱是临床实验室最常用的检测方法之一。然而,以往研究对阻塞性睡眠呼吸暂停(OSA)患者血细胞指标的分析并不全面。本研究旨在全面分析OSA患者的血常规。

研究人员对南方医院睡眠中心20135月至20182月收治的1087例男性患者进行回顾性研究。根据呼吸暂停低通气指数(AHI),患者分为4组,即对照组(AHI < 5, n = 135),轻度OSA(5AHI < 15, n = 185),中度OSA(15AHI < 30, n = 171),重度OSA (AHI30,n = 596)。收集的数据包括睡眠参数、全血常规、体重指数(BMI)、年龄和其它疾病。

本研究中,基于AHI,四组间白细胞、中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性细胞、红细胞、血红蛋白、红细胞压积、血小板、MPVPDWSD均有统计学意义(P < 0.05),但MCVRDWSDN/LP/L比值无统计学差异(P > 0.05)。中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞、血红蛋白、红细胞压积、血小板和MPVAHI呈显著相关。此外,多元线性回归分析表明红细胞比容(β= 73.254,P = 0.001)、中性粒细胞(β= 1.414,P = 0.012)和淋巴细胞(β= 4.228,P < 0.001)AHI独立相关。

因此,研究认为中性粒细胞、淋巴细胞和红细胞压积与OSA的严重程度独立相关。结合这三种血细胞指标有助于OSA诊断

原始出处:

Zeqin Fan, Xiaoxia Lu, The association of hemocyte profile and obstructive sleep apnea

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2020-03-09 tomyang96
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