Alzheimer's & Dementia:ApoE4通过调控炎症和神经营养因子影响阿尔兹海默症

2021-01-30 haibei MedSci原创

实验结果显示,APOE ε4+的pEVs中神经营养和炎症标志物的水平降低。在APOE ε4+的CIND个体中,pEVs中测得的五羟色胺-2/α-synuclein比值能够预测AD发病前5年的情况。

在大脑中,细胞外小泡(EVs)在神经元-胶质细胞界面中起着至关重要的作用,并保证了大脑与外围的串联。目前,一些研究将EVs的通路功能障碍与载脂蛋白E基因变异(APOE ε4)和阿尔茨海默病(AD)的发病风险联系起来。

为了更好地了解APOE ε4在临床前AD中的作用,最近,研究人员测定了外周EVs (pEVs)和认知受损、无痴呆(CIND)参与者血浆中的致病蛋白、神经营养蛋白和炎症蛋白的水平,将APOE的ε4等位基因的缺失(APOE ε4-)或存在(APOE ε4+ )进行分层。

在该研究中,15种神经退行性、神经营养性和神经炎症性蛋白的水平在pEVs中进行定量,并与认知正常的CIND参与者的血浆水平进行比较。

实验结果显示,APOE ε4+的pEVs中神经营养和炎症标志物的水平降低。在APOE ε4+的CIND个体中,pEVs中测得的五羟色胺-2/α-synuclein比值能够预测AD发病前5年的情况

因此,该研究结果表明,APOE ε4+的内膜途径发生了改变,pEVs五羟色胺-2/α-synuclein比值可以作为AD易感性的早期生物标志物

 

原始出处:

Mohamed Raâfet Ben Khedher et al. Apolipoprotein E4–driven effects on inflammatory and neurotrophic factors in peripheral extracellular vesicles from cognitively impaired, no dementia participants who converted to Alzheimer's disease. Alzheimer's & Dementia (2021). 

 

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    2021-02-01 bnjfy
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    2021-02-01 xiongke016

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