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IJC:他汀改善冠脉微血管功能障碍

2011-12-12 我要评论0
Tags: 他汀  微血管  

12月7日,在线发表于《国际心脏病学杂志》(Int J Cardiol)的一项研究论文"Beneficial effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in patients with acute myocardial infarction"表明,他汀除降脂作用外,还能够改善冠脉内皮细胞功能。

近日,日本学者研究表明,他汀治疗似对于急性心肌梗死(AMI)后左室重构的改善有益,其作用可能与通过内源性一氧化氮恢复冠脉内皮功能有关。研究者将35例AMI后行成功的再灌注治疗的患者分为他汀治疗组(S组)和非他汀治疗组(NS组)。采用13N-氨正电子发射断层摄影术评价梗死区域的心肌血流储备(MFR)。

结果显示,在长期治疗中,两组的梗死面积和血脂谱相似。在AMI发生2周后,S组梗死区的平均MFR显著高于NS组[(2.34±0.63)对(1.91±0.43),P=0.0214)。AMI后6个月,S组左心室舒张末容积指数较NS组小[(69.4±11.7) ml/m2 对(88.5±32.5) ml/m2,P =0.0328],而左室射血分数较高[(67.7±9.2)% 对(59.2±13.3)%,P=0.0394]。NS组在AMI后1个月时的血清非对称性二甲基精氨酸较基线水平显著增多,但S组无变化。(生物谷 Bioon.com)

延伸阅读:

BMJ:他汀类药物未能降低感染风险

SATURN:他汀对冠脉硬化斑块负荷变化之影响的最大规模临床研究公布结果

他汀可否用于心血管事件的一级预防?

IJC:他汀改善冠脉微血管功能障碍

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热点PK:大剂量他汀序贯治疗使PCI更上一层楼?

Beneficial effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in patients with acute myocardial infarction

Kentaro Ishida, Toru Geshi, Akira Nakano, Hiroyasu Uzui, Yasuhiko Mitsuke, Hidehiko Okazawa,Takanori Ueda, Jong-Dae Lee

Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARβ/, and ERRs, underpins these phenotypic alterations. NCoR1 levels are decreased in conditions that require fat oxidation, resetting transcriptional programs to boost oxidative metabolism. Knockdown of gei-8, the sole C. elegans NCoR homolog, also robustly increased muscle mitochondria and respiration, suggesting conservation of NCoR1 function. Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function.



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