J Clin Periodontol:肿瘤坏死因子-α转基因小鼠炎症侵袭后的牙周组织和颞下颌关节

2017-12-13 MedSci MedSci原创

肿瘤坏死因子(TNF)-α是引起牙周病和类风湿性关节炎特征性症状的病理因素。在这项研究检测了TNF-α转基因小鼠(hTNFt的牙周组织和颞下颌关节(TMJ)的特征。

肿瘤坏死因子(TNF)-α是引起牙周病和类风湿性关节炎特征性症状的病理因素。在这项研究检测了TNF-α转基因小鼠(hTNFt的牙周组织和颞下颌关节(TMJ)的特征。

材料与方法:通过微型计算机断层摄影术,自动分割,几何形态计量学和组织学切片评估hTNFtg小鼠和野生型(WT)同窝小鼠的牙周结构,TMJ和头骨形状。

结果:与(WT)littermates相比,hTNFtg小鼠硬骨板被侵蚀且牙周膜间隙减小。转基因小鼠有进一步的TMJ严重破坏。几何形态计量学显示,hTNFtg小鼠TMJ侧向移位伴随颧骨增生。咬合正常。

结论:我们的研究结果表明慢性炎症的hTNFtg小鼠会有牙周组织破坏和颞下颌关节的变化。

原始出处:

Toni Dobsak, et al. Impaired periodontium and temporomandibular joints in tumour necrosis factor-α transgenic mice. Journal of Clinical Periodontology. 2017 December. doi:10.1111/jcpe.12799

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    2018-03-25 feather89
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topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Tue May 08 23:41:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633111, encodeId=cf271633111d1, content=<a href='/topic/show?id=c8a6100e6793' target=_blank style='color:#2F92EE;'>#颞下#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100767, encryptionId=c8a6100e6793, topicName=颞下)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dbe822016862, createdName=fengyi819, createdTime=Thu Nov 08 00:41:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362862, encodeId=5714136286216, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450729, encodeId=50d21450e29a0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471916, encodeId=276314e191635, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485449, encodeId=cc2e14854492d, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516261, encodeId=25ad151626123, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=)]
    2018-05-08 xlysu
  5. [GetPortalCommentsPageByObjectIdResponse(id=2037616, encodeId=32f1203e616c1, content=<a href='/topic/show?id=75c1100e6852' target=_blank style='color:#2F92EE;'>#颞下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100768, encryptionId=75c1100e6852, topicName=颞下颌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Mon Nov 05 08:41:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726942, encodeId=00301e26942d9, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Mar 25 02:41:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969711, encodeId=fa781969e1136, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Thu Apr 12 21:41:00 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699706, encodeId=9fca1699e067e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Tue May 08 23:41:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633111, encodeId=cf271633111d1, content=<a href='/topic/show?id=c8a6100e6793' target=_blank style='color:#2F92EE;'>#颞下#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100767, encryptionId=c8a6100e6793, topicName=颞下)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dbe822016862, createdName=fengyi819, createdTime=Thu Nov 08 00:41:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362862, encodeId=5714136286216, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450729, encodeId=50d21450e29a0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471916, encodeId=276314e191635, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485449, encodeId=cc2e14854492d, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516261, encodeId=25ad151626123, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=)]
    2018-11-08 fengyi819
  6. [GetPortalCommentsPageByObjectIdResponse(id=2037616, encodeId=32f1203e616c1, content=<a href='/topic/show?id=75c1100e6852' target=_blank style='color:#2F92EE;'>#颞下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100768, encryptionId=75c1100e6852, topicName=颞下颌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Mon Nov 05 08:41:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726942, encodeId=00301e26942d9, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Mar 25 02:41:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969711, encodeId=fa781969e1136, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Thu Apr 12 21:41:00 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699706, encodeId=9fca1699e067e, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Tue May 08 23:41:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633111, encodeId=cf271633111d1, content=<a href='/topic/show?id=c8a6100e6793' target=_blank style='color:#2F92EE;'>#颞下#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100767, encryptionId=c8a6100e6793, topicName=颞下)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dbe822016862, createdName=fengyi819, createdTime=Thu Nov 08 00:41:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362862, encodeId=5714136286216, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450729, encodeId=50d21450e29a0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471916, encodeId=276314e191635, content=<a href='/topic/show?id=e97a93305ec' target=_blank style='color:#2F92EE;'>#转基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93305, encryptionId=e97a93305ec, topicName=转基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76227191338, createdName=旅苦化文_210, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485449, encodeId=cc2e14854492d, content=<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82871, encryptionId=3879828e19d, topicName=肿瘤坏死因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43077999209, createdName=ms7524819409032184, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516261, encodeId=25ad151626123, content=<a href='/topic/show?id=a5e09331605' target=_blank style='color:#2F92EE;'>#转基因小鼠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93316, encryptionId=a5e09331605, topicName=转基因小鼠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a8010946846, createdName=41514490@qq.com, createdTime=Fri Dec 15 12:41:00 CST 2017, time=2017-12-15, status=1, ipAttribution=)]
    2017-12-15 millore
  7. [GetPortalCommentsPageByObjectIdResponse(id=2037616, encodeId=32f1203e616c1, content=<a href='/topic/show?id=75c1100e6852' target=_blank style='color:#2F92EE;'>#颞下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100768, encryptionId=75c1100e6852, topicName=颞下颌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Mon Nov 05 08:41:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726942, encodeId=00301e26942d9, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  8. 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  9. 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