J Allergy Clin Immunol:靶向Bet v 1的新抗体鸡尾酒能迅速而持续地治疗白桦树过敏症状

2021-07-06 AlexYang MedSci原创

在欧洲和美国,临床上对白桦树花粉的过敏影响了大约20%-30%的过敏人群。

在欧洲和美国,临床上对白桦树花粉的过敏影响了大约20%-30%的过敏人群。

白桦树花粉在树木花粉季节盛行,根据地理位置的不同,盛行时间在冬末至夏初的4至8周内。白桦树花粉含有混合的致敏和非致敏蛋白,其中Bet v 1是免疫优势和最丰富的致敏蛋白。据报道,白桦树过敏者对Bet v 1的过敏率高达95%以上。

过敏原特异性IgG混合治疗猫过敏的疗效表明,过敏原特异性IgG可能是由过敏原免疫疗法引起的一种主要保护机制。为了扩展这些发现,近期,有研究人员在白桦树过敏的受试者中测试了Bet v 1特异性抗体鸡尾酒疗法

研究是一期、随机、双盲的研究。A部分,在32名健康受试者中使用递增剂量的Bet v 1-特异性抗体鸡尾酒 "REGN5713/14/15" (150-900 mg);B部分,在64名桦树过敏受试者中使用单次皮下900 mg剂量或安慰剂。在筛查和第8、29、57和113天(仅SPT)评估鼻部症状总分(TNSS)对滴定白桦树提取物鼻腔过敏原挑战(NAC)和白桦树和赤杨树过敏原皮刺试验(SPT)的反应;还进行了嗜碱细胞活化试验(n=26)。

相对于基线,单剂量REGN5713/14/15显著降低了桦木NAC后的TNSS。与安慰剂相比,TNSS的AUC(0-1小时)差异(第8天:-1.17,P=0.001;第29天:-1.18,P=.001;第57天:-0.85,P=0.024)和滴定白桦树SPT的AUC差异(所有P<0.001)持续了≥2个月;在赤杨树SPT观察到了类似结果。另外,REGN5713/14/15耐受性良好。更多的是,REGN5713/14/15治疗的受试者与安慰剂相比,在第8天、第57天和第113天,嗜碱细胞对白桦树相关过敏原的反应性明显下降(所有P<0.01)。

单剂量REGN5713/14/15 900mg SC治疗效果

综上所述,单剂量REGN5713/14/15的耐受性良好,并能快速(1周)和持久(2个月)地减少桦树过敏原NAC后的过敏症状,为治疗白桦树过敏症状提供了一个新的范例

原始出处:

Philippe Gevaert , Jarno De Craemer , Natalie De Ruyck et al. Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a Phase 1 study. J Allergy Clin Immunol. Jun 2021

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    2021-07-08 膀胱癌
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    2021-07-08 qblt

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