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JAHA：肉毒碱水平与HIV携带者心梗风险呈相关性

2019-04-28 不详 MedSci原创

心血管肉毒碱HIV
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HIV携带者（PLWH）心梗的风险会更高。慢性HIV感染引起的肠道菌群失调可能与HIV相关性动脉粥样硬化相关，胆碱、肉碱、甜菜碱和三甲胺N-氧化物是部分由肠道微生物群代谢或产生的小分子。本研究推测这些代谢物与PLWH的颈动脉内膜中层厚度和心梗相关。本研究纳入了SCOPE队列中的162名PLWH，并对其基线水平和4年后的颈动脉内膜中层厚度进行了测量，结果显示高水平的肉毒碱与颈动脉斑块的存在和颈动脉内

HIV携带者（PLWH）心梗的风险会更高。慢性HIV感染引起的肠道菌群失调可能与HIV相关性动脉粥样硬化相关，胆碱、肉碱、甜菜碱和三甲胺N-氧化物是部分由肠道微生物群代谢或产生的小分子。本研究推测这些代谢物与PLWH的颈动脉内膜中层厚度和心梗相关。

本研究纳入了SCOPE队列中的162名PLWH，并对其基线水平和4年后的颈动脉内膜中层厚度进行了测量，结果显示高水平的肉毒碱与颈动脉斑块的存在和颈动脉内膜中层厚度的进展呈强相关，且独立于传统心血管危险因素。另外，在调整心血管疾病危险因素后，肉碱水平最高的四分位数受试者心肌梗死的风险显着增加。

研究结果显示，在HIV携带者中，肉毒碱水平与颈动脉斑块、颈动脉内膜中层厚度和心梗呈独立相关性。

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    2019-08-31 qblt

    #携带者#

    0

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    2019-10-12 shenxlcyp

    #相关性#

    0

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    2020-03-19 cy0324

    #心梗风险#

    0

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    2019-05-06 苏小雨

    非常好，学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2004926, encodeId=991b20049264e, content=<a href='/topic/show?id=2f48569264d' target=_blank style='color:#2F92EE;'>#携带者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56926, encryptionId=2f48569264d, topicName=携带者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Sat Aug 31 23:49:00 CST 2019, time=2019-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837674, encodeId=8c3a183e674bc, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat Oct 12 02:49:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016098, encodeId=b9d32016098f9, content=<a href='/topic/show?id=1f5a510e731' target=_blank style='color:#2F92EE;'>#心梗风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51077, encryptionId=1f5a510e731, topicName=心梗风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Mar 19 14:49:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365800, encodeId=d4a136580069, content=非常好，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/05/22/c26524b0b4ca80000d38f0294262c002.jpg, createdBy=3cf52015303, createdName=苏小雨, createdTime=Mon May 06 07:18:03 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365799, encodeId=eb13365e996c, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/05/22/c26524b0b4ca80000d38f0294262c002.jpg, createdBy=3cf52015303, createdName=苏小雨, createdTime=Mon May 06 07:17:52 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268128, encodeId=15881268128c0, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Apr 30 14:49:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365448, encodeId=3e1936544853, content=谢谢了，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Mon Apr 29 07:20:45 CST 2019, time=2019-04-29, status=1, ipAttribution=)]
    2019-05-06 苏小雨

    厉害

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2004926, encodeId=991b20049264e, content=<a href='/topic/show?id=2f48569264d' target=_blank style='color:#2F92EE;'>#携带者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56926, encryptionId=2f48569264d, topicName=携带者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Sat Aug 31 23:49:00 CST 2019, time=2019-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837674, encodeId=8c3a183e674bc, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat Oct 12 02:49:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016098, encodeId=b9d32016098f9, content=<a href='/topic/show?id=1f5a510e731' target=_blank style='color:#2F92EE;'>#心梗风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51077, encryptionId=1f5a510e731, topicName=心梗风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Mar 19 14:49:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365800, encodeId=d4a136580069, content=非常好，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/05/22/c26524b0b4ca80000d38f0294262c002.jpg, createdBy=3cf52015303, createdName=苏小雨, createdTime=Mon May 06 07:18:03 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365799, encodeId=eb13365e996c, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/05/22/c26524b0b4ca80000d38f0294262c002.jpg, createdBy=3cf52015303, createdName=苏小雨, createdTime=Mon May 06 07:17:52 CST 2019, time=2019-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268128, encodeId=15881268128c0, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Apr 30 14:49:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365448, encodeId=3e1936544853, content=谢谢了，学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Mon Apr 29 07:20:45 CST 2019, time=2019-04-29, status=1, ipAttribution=)]
    2019-04-30 仁心济世

    #AHA#

    0

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    2019-04-29 txqjm

    谢谢了，学习

    0

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