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J Biomater Appl：Dimethyloxalylglycine可改善ZIF-8涂层植入物的血管生成

2019-05-24 不详 网络

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具有一定密度的纳米级沸石咪唑酯骨架-8涂层可以在体外和体内显著改善钛植入物的成骨活性。在该研究中，我们将二甲基肟基甘氨酸加载到沸石咪唑酯骨架-8-修饰的植入物（Z-AHT）中以增强血管生成活性，并且将所得产物表示为D-AHT。首先，我们通过扫描电子显微镜，傅里叶变换红外光谱，粉末X射线衍射和表面接触角对样品进行了表征。然后，研究了锌离子和二甲基肟基甘氨酸的释放动力学。为了说明表面形貌和化学（沸石咪

具有一定密度的纳米级沸石咪唑酯骨架-8涂层可以在体外和体内显著改善钛植入物的成骨活性。在该研究中，我们将二甲基肟基甘氨酸加载到沸石咪唑酯骨架-8-修饰的植入物（Z-AHT）中以增强血管生成活性，并且将所得产物表示为D-AHT。

首先，我们通过扫描电子显微镜，傅里叶变换红外光谱，粉末X射线衍射和表面接触角对样品进行了表征。然后，研究了锌离子和二甲基肟基甘氨酸的释放动力学。为了说明表面形貌和化学（沸石咪唑酯骨架-8和二甲基肟基甘氨酸）对成骨和血管生成活性的综合影响，分别在D-AHT上培养MC3T3-E1前成骨细胞和人脐静脉内皮细胞。将纯Ti和Z-AHT指定为对照组。

结果，成骨基因（Alp，Col1，Opg和Runx2）的表达和ALP蛋白的分泌显示D-AHT显示出与Z-AHT相当的成骨活性，且其优于Ti。进一步的血管生成测定揭示了在D-AHT上更好的人脐静脉内皮细胞迁移，表明D-AHT可以是用于植入物表面修饰的有吸引力的候选物。

原始出处：

Zhang X, Wang J, et al., Dimethyloxalylglycine improves angiogenesis of ZIF-8-coated implant. J Biomater Appl. 2019 May 22:885328219850976. doi: 10.1177/0885328219850976. 

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    2020-02-15 kalseyzl

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    2020-04-14 一闲

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    2019-07-25 sunylz

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    2019-05-26 linagood

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    2019-05-26 jiyangfei

    #植入#

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