Gastroenterology:益生元降低身脂并改变超重或肥胖儿童肠道菌群

2017-06-07 zhangfan MedSci原创

低聚果糖菊粉可改变肠道菌群组成,显著降低超重或肥胖青少年的体重指数、体脂含量及炎症指标

长期以来,人们认为益生元类药物可以通过肠道菌群调节人体机能,最新研究发现益生元可特异性的改变肠道菌群降低超重/肥胖儿童体重。近日研究人员开展随机对照试验就益生元对超重或肥胖儿童的身体组成、炎症标记物、粪便中胆汁酸和肠道菌群组成的作用开展研究。

在这项单中心,双盲安慰剂对照研究中,参与者为7-12岁的超重或肥胖儿童,无其他基础疾病。参与者随机接受低聚果糖菊粉 (OI, 8 g/天; n=22) 或麦芽糊精安慰剂(n=20),研究持续16周。使用双能量X射线骨密度仪测量脂肪量和瘦体重。基线和每4周测量身高、体重和腰围。基线及16周收集血液样本,分析血脂,细胞因子,脂多糖和胰岛素。基线和16周收集粪便样品测定胆汁酸含量和微生物组成分析。研究的主要终点是从基线到16周时身体脂肪百分比变化。

研究发现,16周时,服用OI的参与者其体重指数(降低3.1%)、体脂百分数(降低2.4%)和躯干脂肪(降低3.8%)显著降低,而安慰剂儿童相应指标增长了0.5%、0.05%和下降0.3%。OI组IL6水平显著下降(下降15%vs增长25%)。OI组血清甘油三酯减少19%。OI组双歧杆菌数量显著增加,普通拟杆菌数量减少。粪便样本中,对照组的初级胆汁酸水平高于OI组。

研究认为,低聚果糖菊粉可改变肠道菌群组成,显著降低超重或肥胖青少年的体重指数、体脂含量及炎症指标。

原始出处:


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    2017-11-03 许安
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  5. 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  6. 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2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392251, encodeId=6ed2139225150, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Thu Jun 08 23:36:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207774, encodeId=d8ba20e774c7, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jun 07 16:34:17 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207753, encodeId=d5fb20e753dd, content=哈哈,还需进一步研究才能下结论, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=19ad2070095, createdName=赵淘淘, createdTime=Wed Jun 07 15:28:08 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-08 mnda
  7. 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  8. 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  9. 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2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392251, encodeId=6ed2139225150, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Thu Jun 08 23:36:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207774, encodeId=d8ba20e774c7, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jun 07 16:34:17 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207753, encodeId=d5fb20e753dd, content=哈哈,还需进一步研究才能下结论, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=19ad2070095, createdName=赵淘淘, createdTime=Wed Jun 07 15:28:08 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 Y—xianghai

    学习了新知识

    0

  10. 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2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392251, encodeId=6ed2139225150, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Thu Jun 08 23:36:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207774, encodeId=d8ba20e774c7, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jun 07 16:34:17 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207753, encodeId=d5fb20e753dd, content=哈哈,还需进一步研究才能下结论, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=19ad2070095, createdName=赵淘淘, createdTime=Wed Jun 07 15:28:08 CST 2017, time=2017-06-07, status=1, ipAttribution=)]
    2017-06-07 赵淘淘

    哈哈,还需进一步研究才能下结论

    0

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