ARCH PATHOL LAB MED：食管远端组织活检中的胰腺腺泡化生与慢性非甾体抗炎药物的使用有关

2019-05-09 不详网络

目前对于胰腺腺泡化生(PAM)发生在食管远端/食管胃交界处的原因仍有争议。尽管一些研究人员认为它是先天性的，但另一些认为它是由于胃贲门炎症而引起的，最近一项基于大鼠的研究表明，它是由于慢性质子泵抑制剂的使用而引发的。本研究的目的是确定慢性质子泵抑制剂的使用与人类PAM之间是否存在相关性。还研究了几种临床和病理因素与PAM的关系。

目前对于胰腺腺泡化生(PAM)发生在食管远端/食管胃交界处的原因仍有争议。尽管一些研究人员认为它是先天性的，但另一些认为它是由于胃贲门炎症而引起的，最近一项基于大鼠的研究表明，它是由于慢性质子泵抑制剂的使用而引发的。本研究的目的是确定慢性质子泵抑制剂的使用与人类PAM之间是否存在相关性。还研究了几种临床和病理因素与PAM的关系。

研究人员回顾了来自食管远端/食管胃交界处的444例连续活检，以确定PAM的存在，并与一些临床和病理结果相关联。

研究显示，71例(16%)出现胰腺腺泡化生。胰腺腺泡化生与患者年龄小于51岁(P < .001)、慢性心脏病(P = .01)和慢性质子泵抑制剂使用显著相关(P = .008)。令人惊讶的是，研究人员还发现PAM与慢性非甾体抗炎药物使用之间存在显著的相关性(P < .001)。这些关联，包括慢性非甾体抗炎药物的使用，在多变量分析中仍然显著。

本研究结果证实了先前关于PAM与慢性心脏病之间存在显著关联的报道，以及动物实验中关于使用慢性质子泵抑制剂的研究结果。但与慢性非甾体类抗炎药物的使用密切相关的研究尚未见报道，仍需要进一步的研究。

原始出处：

Suhair Al Salihi, MD; Vanya Jaitly, MD;Pancreatic Acinar Metaplasia in Distal Esophageal Biopsies Is Associated With Chronic Nonsteroidal Anti-inflammatory Drug Use

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2020-04-17 yb6560

#Pathol#

31 0
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2019-05-11 仁者大医

#活检#

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2019-05-11 ms8888626721583891

#非甾体抗炎药#

46 0
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2019-05-11 xinmeili

#抗炎药#

62 0
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2019-05-11 zhouqu_8

#食管#

37 0
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2019-05-11 ms3994565386320060

#Med#

30 0
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2019-05-11 xfpan19

#组织活检#

36 0

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ARCH PATHOL LAB MED：食管远端组织活检中的胰腺腺泡化生与慢性非甾体抗炎药物的使用有关

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