Chest:慢性阻塞性肺疾病患者肺康复训练对病情恶化次数和严重程度的影响!

2017-06-01 xing.T MedSci原创

本研究发现, 不足10%的适合进行PR的患者实际接受了PR训练。适合进行PR治疗且接受了PR训练的(但并不一定完成)患者并没有减少因AECOPD而GP就诊和住院,在PR训练一年后,相比于没有进行PR训练的患者或与PR前一年。

之前的系统评价,主要针对随机对照试验,已证实肺康复(PR)能减少因COPD急性加重(AECOPD)而住院。然而,队列研究的结果并不一致。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员旨在比较PR治疗前后AECOPD住院和接受全科医生(GP)治疗的发生情况。

研究人员从临床实践研究数据链和医院发作统计局获得匿名数据,研究人员比较了PR前1年和PR后AECOPD住院和GP就诊情况。同时,也比较了复合条件的进行PR患者和复合条件的未进行PR患者COPD恶化率。

队列中69089名(64%)COPD患者适合进行PR治疗,只有6436名(9.3%)参与者记录进行了康复训练。62019名(89.8%)未进行康复训练,并且有634名(0.98%)参与者拒绝转诊。一旦结合GP治疗和医院病情加重时,那些有适合PR的患者进行PR训练的患者略有增加,但无统计学意义(2.83次加重恶化/患者每年,95%可信区间为2.66-3.00),相比于那些适合但未进行PR训练的患者(2.17次加重恶化/患者每年,95%可信区间为2.11-2.24)。

本研究发现, 不足10%的适合进行PR的患者实际接受了PR训练。适合进行PR治疗且接受了PR训练的(但并不一定完成)患者并没有减少因AECOPD而GP就诊和住院,在PR训练一年后,相比于没有进行PR训练的患者或与PR前一年。

原始出处:


Elizabeth Moore,et al. Effects of pulmonary rehabilitation on exacerbation number and severity in people with COPD: An historical cohort study using electronic health records.chest.2017. http://journal.publications.chestnet.org/article.aspx?articleid=2629210

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    2017-06-10 tomyang96
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  5. 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  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929348, encodeId=c1c0192934877, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Jan 11 06:40:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205990, encodeId=009920599055, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Jun 03 11:28:25 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205683, encodeId=7caf20568388, content=这个文章不错,可以看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jun 02 17:39:26 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1765008, encodeId=1b6a1e6500875, content=<a href='/topic/show?id=df00e086653' target=_blank style='color:#2F92EE;'>#病情#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70866, encryptionId=df00e086653, topicName=病情)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Mar 07 14:40:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696724, encodeId=a9b21696e2478, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, 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content=<a href='/topic/show?id=9c4f821156f' target=_blank style='color:#2F92EE;'>#肺康复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82115, encryptionId=9c4f821156f, topicName=肺康复)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Fri Oct 06 04:40:00 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798983, encodeId=85501e9898346, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Wed Nov 01 01:40:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929348, encodeId=c1c0192934877, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Jan 11 06:40:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205990, encodeId=009920599055, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Jun 03 11:28:25 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205683, encodeId=7caf20568388, content=这个文章不错,可以看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jun 02 17:39:26 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
    2018-01-11 Smile2680
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929348, encodeId=c1c0192934877, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Jan 11 06:40:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205990, encodeId=009920599055, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Jun 03 11:28:25 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205683, encodeId=7caf20568388, content=这个文章不错,可以看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jun 02 17:39:26 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
    2017-06-03 changjiu

    学习了,谢谢

    0

  10. 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content=<a href='/topic/show?id=9c4f821156f' target=_blank style='color:#2F92EE;'>#肺康复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82115, encryptionId=9c4f821156f, topicName=肺康复)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Fri Oct 06 04:40:00 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798983, encodeId=85501e9898346, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Wed Nov 01 01:40:00 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929348, encodeId=c1c0192934877, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Jan 11 06:40:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205990, encodeId=009920599055, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Jun 03 11:28:25 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205683, encodeId=7caf20568388, content=这个文章不错,可以看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Jun 02 17:39:26 CST 2017, time=2017-06-02, status=1, ipAttribution=)]
    2017-06-02 1e1b8538m79(暂无匿称)

    这个文章不错,可以看看

    0

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由此可见,血清中SIRT1(s120s)在COPD患者中有所降低,可能反映了降低了氧化应激细胞内的SIRT1,并可能作为COPD某些疾病特征的潜在生物标志。

SCI REP:伴COPD的肺腺癌患者LRP1B突变率更高

慢性阻塞性肺病(COPD)以及肺癌是常见的肺部疾病,常共同发生。有研究表明COPD会增加肺癌发生的风险,这一现象表明COPD与肺癌发生之间存在着某种联系。人们提出了多种理论如氧化应激、遗传易感性、表观遗传学改变、炎性环境改变等来联系COPD与肺癌,但是COPD与肺癌发生之间联系的分子机制尚不明确。

ATS2017:即使无COPD,吸烟者仍然面临着较高的死亡风险!

在一项新的研究中,CT测量的血管修剪——远端肺血管(肺外缘血管)的减少与没有慢性阻塞性肺疾病(COPD)的吸烟者的死亡风险增加相关。该研究在2017年美国胸科协会国际会议上提出。

JAMA:严重肺病又不想住院?福音来了!

患有严重肺部疾病的患者可能会因为英国由位于伦敦的Guy's和St Thomas的Lane Fox呼吸服务团队领导的专家进行的“游戏变化”临床试验而转变生活。

ATS 2017:慢性阻塞性肺病恶化需谨慎,小心心脏病发作!

根据ATS 2017国际组织会议,在急性加重慢性阻塞性肺疾病之后,有心血管疾病史(CVD)或心血管疾病风险的患者似乎更容易遭受心脏病发作或中风。

ATS 2017:吸烟者请注意:身体发生这一变化很可能是致命的!

吸烟会导致多种疾病。新的研究表明,胸部肌肉量越少,由于吸烟导致的死亡风险越高。来自疾病控制和预防中心(CDC)报告表示,吸烟是可预防疾病和死亡的第一大原因,