JAHA:晚期心衰患者室性心律失常的情况

2021-12-25 MedSci原创 MedSci原创

左心室射血分数<40%和既往VA的患者出现晚期HF后严重VA的风险增加。新发严重VAs或没有植入式心律转复除颤器的严重VAs与HF后死亡率增加相关。

心力衰竭(HF)是一种慢性、进行性疾病,在美国影响了超过600万人。尽管在HF治疗方面取得了巨大进步,但一些患者仍会出现HF症状,这与目前可用的基于指南的疗法相悖。晚期HF患者室性心律失常(VA)的流行病学数据仍未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在使用2018年欧洲心脏病学会标准确定的明尼苏达州奥姆斯特德县2007年至2017年期间晚期HF的居民。计费代码用于捕获VA;需要紧急治疗的严重VA被定义为与急诊就诊或住院相关的事件。

研究人员使用Kaplan-Meier方法估计了晚期HF的VAs累积发生率。多变量Cox分析用于明确以下内容:(1)晚期HF患者严重VAs的预测因素;(2)严重VAs对死亡率的影响。

在936名晚期HF患者中,261名(27.9%)患者有VA病史。晚期HF患者严重VA的1年累积发生率为5.4%。既往VA(风险比[HR]为2.22[95%CI为1.26-3.89],P=0.006)和左心室射血分数<40%(HR为3.79[95%CI为1.72-8.39],P<0.001)与晚期HF后严重VA风险增加独立相关。新发重度VA与死亡率增加相关(HR为4.41[95%CI为2.80-6.94];P<0.001),而既往VA患者的重度VA与死亡风险没有显著相关性(HR为1.08[95%CI为0.65-1.78];P=0.77)。在没有植入式心脏复律除颤器的患者中,严重的VA与死亡率增加相关(HR为4.89[95%CI为2.89-8.26];P<0.001),但在植入式心脏复律除颤器的患者中则不然(HR为1.42[95%CI为0.92-2.19];P=0.11)。

由此可见,左心室射血分数<40%和既往VA的患者出现晚期HF后严重VA的风险增加。新发严重VAs或没有植入式心律转复除颤器的严重VAs与HF后死亡率增加相关。

原始出处:

Nicholas Y. Tan,et al.Ventricular Arrhythmias Among Patients With Advanced Heart Failure: A Population‐Based Study.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.023377

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    2021-12-27 zhaohui6731
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