心脏瓣膜置换术后患者行全髋关节置换术麻醉1例

2018-09-28 侯景利 王志勇 牟荟君 西南国防医药

女性,58岁,因摔伤后致左股骨颈骨折1w入院。既往患“风心病,房颤”,17年前因"脑梗塞"致左侧肢体不全瘫,肌力Ⅲ级;7年前行“二尖瓣及主动脉瓣置换术”,术毕持续口服华法林至入院前。

1.病例
 
女性,58岁,因摔伤后致左股骨颈骨折1w入院。既往患“风心病,房颤”,17年前因"脑梗塞"致左侧肢体不全瘫,肌力Ⅲ级;7年前行“二尖瓣及主动脉瓣置换术”,术毕持续口服华法林至入院前。
 
入院时心功能评估为Ⅲ级。入院后停华法林,予左下肢牵引术。查体:双下肢无肿胀、皮肤无瘀斑,双肺散在哮鸣音,精神、饮食差。心电图报告“房颤,心室率122次/min”;心脏彩超提示“左房、右房、右室扩大、左室收缩及舒张功能降低,EF值32%、FS值13%”。胸片显示“双肺纹理增粗,心胸比0.83”。
 
化验检查:凝血酶原时间标准比值[PT(INR)]3.52、血红蛋白浓度(HGB)102g/L,血小板及电解质正常。停华法林7d后PT(INR)降至1.58,行左侧全髋关节置换术。术前1d患者不能平卧,考虑心功能不全,给予口服双氢克尿噻25mg。麻醉过程:入室后开放静脉,常规监测。患者房颤心律,心室率约110次/min,SpO2 92%,血压125/80mmHg。采用腰丛神经阻滞复合浅全麻。右侧卧位下经神经刺激器以0.25%罗哌卡因30ml行腰丛阻滞。因体位受限,未行坐骨神经阻滞。
 
全麻诱导:咪唑安定1.5mg、顺阿曲库铵8mg、芬太尼0.15mg、依托咪酯10mg。插管成功后行右颈内静脉置管。吸入0.4%七氟醚、静脉泵注右美托咪定0.3~0.5μg/(kg·h)及瑞芬太尼0.2mg/h维持麻醉。患者摆右侧卧位后,血压突然降至55/30mmHg,立即减浅麻醉,予西地兰0.2mg、麻黄碱6mg静注后血压升至90/50mmHg。术中生命体征平稳,按需追加芬太尼及顺阿曲库铵。手术历时2h,出血约400ml,术野未见明显渗血;术中共输注红细胞悬液2U,新鲜冰冻血浆150ml,钠钾镁钙葡萄糖注射液1000ml,羟乙基淀粉注射液500ml。
 
术毕患者清醒拔管,血压升至120/90mmHg、心室率140次/min,给予速尿10mg、西地兰0.2mg静注,术中尿量共200ml;双肺仍存在哮鸣音,予沙丁胺醇口腔喷雾及甲强龙40mg静注;托烷司琼5mg静注后,以舒芬太尼4μg/h行患者自控术后镇痛。返回病房后继续给予强心、利尿等治疗。术后12h开始口服华法林,下肢穿戴弹力袜,未见伤口明显渗血及静脉血栓形成。术后24h内VAS评分2分。
 
2.讨论
 
该患者病情复杂,麻醉及手术风险极大,辗转多家医院后患者及家属强烈要求手术。因患者既往有脑梗死病史,为防止血栓形成,停华法林7d后未等到PT(INR)降至1.4以下即行手术;为防止术中出现大出血,术前亦未行肝素替代疗法。根据2014版《凝血功能障碍患者区域麻醉与镇痛管理的专家共识》,PT(INR)在1.41~1.7之间需进一步个体评估。该患者已行心脏瓣膜置换术7年,心脏储备功能很低,EF值仅32%、FS值仅13%,而心胸比高达0.83,麻醉耐受性极差。
 
笔者认为采取腰丛神经阻滞复合浅全麻的方式,加强了镇痛效果,减轻应激反应,又避免了深麻醉对心脏的抑制,虽有穿刺出血风险,但对患者而言利大于弊。术中持续泵注右美托咪定,既有镇静、镇痛效果,减少全麻药用量,又可在一定程度上减缓心率、维持心功能,术后随访患者亦无术中知晓发生。因考虑到体位改变的因素,未在中心静脉压力持续监测下指导强心、补液、利尿等治疗,乃本病例不足之处。此类患者如术中能够进行心脏超声监测,将显著提高麻醉安全性。 
 
原始出处:

侯景利, 王志勇, 牟荟君,等. 心脏瓣膜置换术后患者行全髋关节置换术麻醉1例[J]. 西南国防医药, 2017, 27(1):90-90.

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GetPortalCommentsPageByObjectIdResponse(id=1715950, encodeId=6b631e1595091, content=<a href='/topic/show?id=2c375156e5f' target=_blank style='color:#2F92EE;'>#心脏瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51567, encryptionId=2c375156e5f, topicName=心脏瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b6d32099965, createdName=jianjun77, createdTime=Wed Apr 17 04:18:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576642, encodeId=7a7f15e664239, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583585, encodeId=29211583585a3, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347154, encodeId=516434e154eb, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
    2019-09-07 yxch48
  4. [GetPortalCommentsPageByObjectIdResponse(id=1798304, encodeId=1fb51e9830477, content=<a href='/topic/show?id=bb9868e9018' target=_blank style='color:#2F92EE;'>#瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68790, encryptionId=bb9868e9018, topicName=瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Aug 23 23:18:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754194, encodeId=5a661e54194a2, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050736663344, createdName=apoenzyme, createdTime=Sun Jan 06 05:18:00 CST 2019, time=2019-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742524, encodeId=3f911e42524cd, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sat Sep 07 02:18:00 CST 2019, time=2019-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022006, encodeId=aa532022006f5, content=<a href='/topic/show?id=3d3929e567d' target=_blank style='color:#2F92EE;'>#全髋关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1715950, encodeId=6b631e1595091, content=<a href='/topic/show?id=2c375156e5f' target=_blank style='color:#2F92EE;'>#心脏瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51567, encryptionId=2c375156e5f, topicName=心脏瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b6d32099965, createdName=jianjun77, createdTime=Wed Apr 17 04:18:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576642, encodeId=7a7f15e664239, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583585, encodeId=29211583585a3, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347154, encodeId=516434e154eb, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1798304, encodeId=1fb51e9830477, content=<a href='/topic/show?id=bb9868e9018' target=_blank style='color:#2F92EE;'>#瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68790, encryptionId=bb9868e9018, topicName=瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Aug 23 23:18:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754194, encodeId=5a661e54194a2, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1715950, encodeId=6b631e1595091, content=<a href='/topic/show?id=2c375156e5f' target=_blank style='color:#2F92EE;'>#心脏瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51567, encryptionId=2c375156e5f, topicName=心脏瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b6d32099965, createdName=jianjun77, createdTime=Wed Apr 17 04:18:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576642, encodeId=7a7f15e664239, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583585, encodeId=29211583585a3, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347154, encodeId=516434e154eb, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1798304, encodeId=1fb51e9830477, content=<a href='/topic/show?id=bb9868e9018' target=_blank style='color:#2F92EE;'>#瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68790, encryptionId=bb9868e9018, topicName=瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Aug 23 23:18:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754194, encodeId=5a661e54194a2, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=29756, encryptionId=3d3929e567d, topicName=全髋关节)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Thu Jan 03 21:18:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988537, encodeId=6c2d198853e59, content=<a href='/topic/show?id=d2fa515e541' target=_blank style='color:#2F92EE;'>#心脏瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51575, encryptionId=d2fa515e541, topicName=心脏瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Sat May 04 20:18:00 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715950, encodeId=6b631e1595091, content=<a href='/topic/show?id=2c375156e5f' target=_blank style='color:#2F92EE;'>#心脏瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51567, encryptionId=2c375156e5f, topicName=心脏瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b6d32099965, createdName=jianjun77, createdTime=Wed Apr 17 04:18:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576642, encodeId=7a7f15e664239, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583585, encodeId=29211583585a3, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347154, encodeId=516434e154eb, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1798304, encodeId=1fb51e9830477, content=<a href='/topic/show?id=bb9868e9018' target=_blank style='color:#2F92EE;'>#瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68790, encryptionId=bb9868e9018, topicName=瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Aug 23 23:18:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754194, encodeId=5a661e54194a2, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1798304, encodeId=1fb51e9830477, content=<a href='/topic/show?id=bb9868e9018' target=_blank style='color:#2F92EE;'>#瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68790, encryptionId=bb9868e9018, topicName=瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Aug 23 23:18:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754194, encodeId=5a661e54194a2, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1715950, encodeId=6b631e1595091, content=<a href='/topic/show?id=2c375156e5f' target=_blank style='color:#2F92EE;'>#心脏瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51567, encryptionId=2c375156e5f, topicName=心脏瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b6d32099965, createdName=jianjun77, createdTime=Wed Apr 17 04:18:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576642, encodeId=7a7f15e664239, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
  9. 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createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583585, encodeId=29211583585a3, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347154, encodeId=516434e154eb, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
    2018-09-28 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1798304, encodeId=1fb51e9830477, content=<a href='/topic/show?id=bb9868e9018' target=_blank style='color:#2F92EE;'>#瓣膜置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68790, encryptionId=bb9868e9018, topicName=瓣膜置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Fri Aug 23 23:18:00 CST 2019, time=2019-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754194, encodeId=5a661e54194a2, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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GetPortalCommentsPageByObjectIdResponse(id=1715950, encodeId=6b631e1595091, content=<a href='/topic/show?id=2c375156e5f' target=_blank style='color:#2F92EE;'>#心脏瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51567, encryptionId=2c375156e5f, topicName=心脏瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b6d32099965, createdName=jianjun77, createdTime=Wed Apr 17 04:18:00 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576642, encodeId=7a7f15e664239, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583585, encodeId=29211583585a3, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Sun Sep 30 10:18:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347154, encodeId=516434e154eb, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:53:30 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347153, encodeId=389034e153d7, content=不错的文章值得拥有哦哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Sep 28 22:51:51 CST 2018, time=2018-09-28, status=1, ipAttribution=)]
    2018-09-28 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦哦

    0

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