J Thromb Haemost:生长分化因子-15可用于预测癌症患者出血性事件

2021-10-22 MedSci原创 MedSci原创

这项研究表明GDF-15可预测接受血栓预防治疗的癌症患者出血事件。

生长分化因子15(GDF-15)是房颤患者出血的较强的预测因子,但没有关于该生物标志物在癌症患者血管结局的数据。在考虑初级血栓预防时,出血风险评估对癌症患者很重要,因为它与出血风险增加有关。

近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在评估GDF-15作为癌症患者出血事件预测因子的疗效。

在这项试验中,574名参与者被随机分配到预防性阿哌沙班治疗组或安慰剂组,并随访180天的静脉血栓栓塞、大出血、临床相关的非大出血和任何出血。研究人员使用Elecsys GDF-15商业化验试剂盒(罗氏公司)集中检测血浆中GDF-15的浓度。

在接受阿哌沙班治疗者中,GDF-15预测大出血的受试者-操作特征曲线下面积为0.73(95%CI为为0.44-1.00)。与最低GDF-15三分位数(<1470ng/L)相比,最高三分位数(≥2607ng/L;危险比[HR]为3.19;95%CI为2.41-4.22)的大出血风险显著更高,同样在调整性别、年龄、抗血小板药物使用和胃肠道癌症时(调整后的HR为2.80;95%CI为1.91-4.11)。GDF-15浓度还与临床相关的非大出血(调整后的HR为1.67,95%CI为1.08-2.58)和任何出血(调整后的HR为2.12,95%CI为1.38-3.25)显著相关。

由此可见,这项研究表明GDF-15可预测接受血栓预防治疗的癌症患者出血事件。

原始出处:
 
Frits I. Mulder.et al.Growth differentiation factor-15 for prediction of bleeding in cancer patients.Journal of Thrombosis and Haemostasis.2021. https://doi.org/10.1111/jth.15559

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    2022-09-23 changfy
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    2021-10-23 查查佳佳

    睡眠障碍可能是导致这种风险的一个未确

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