Endocrinology：研究人员发现预防I型糖尿病的方法

2015-02-03 MedSci MedSci原创

由圣路易斯大学药理和生理科学主席托马斯•伯里斯博士报告的，一项发表在内分泌学上的新研究显示，他的团队在动物模型上已经找到了一种方法来防止I型糖尿病。 I型糖尿病是一种慢性自身免疫性疾病，当人体的免疫系统破坏胰岛素产生的胰腺β细胞时会导致I型糖尿病,表观为胰岛素缺乏和高血糖。目前治疗I型糖尿病关注点在通过胰岛素治疗控制血糖，但整个一生必须继续这种治疗。伯里斯和他的研究小组专注研究阻止因β细胞损

由圣路易斯大学药理和生理科学主席托马斯•伯里斯博士报告的，一项发表在内分泌学上的新研究显示，他的团队在动物模型上已经找到了一种方法来防止I型糖尿病。

I型糖尿病是一种慢性自身免疫性疾病，当人体的免疫系统破坏胰岛素产生的胰腺β细胞时会导致I型糖尿病,表观为胰岛素缺乏和高血糖。目前治疗I型糖尿病关注点在通过胰岛素治疗控制血糖，但整个一生必须继续这种治疗。

伯里斯和他的研究小组专注研究阻止因β细胞损伤而导致糖尿病的自身免疫过程 ,目的是开发一种治疗方法,防止疾病的发展而不是治疗该症状。”我们相信这种治疗将延缓I型糖尿病的发展进程，或消除胰岛素治疗的需求,”伯里斯说。

科学家们已经知道,至少有两种类型的免疫T细胞”对I型糖尿病的发展有关联。然而,第三种类型的细胞TH17仍不清楚。

在这项研究中,研究人员发现，两个核受体对TH17细胞的发展起了关键作用，针对这些受体，他们在小鼠模型上能够阻止自身免疫的发展，从而保护β细胞。

团队在老鼠模型上实验发现，阻止ROR阿尔法和伽马t受体，即选择性ROR阿尔法和伽马t逆受体激动剂——SR1001，SR1001显著降低糖尿病的发病率，并治疗小鼠的胰岛炎。

这些结果证实，TH17细胞针对于I型糖尿病的发展发挥了关键作用，建议使用基于这种细胞靶标的药物，这可能会提供一种治疗这种疾病的新方法。

原始出处

Laura A. Solt, Subhashis Banerjee, Sean Campbell, Theodore M. Kamenecka, Thomas P. Burris. ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes. Endocrinology, 2015; en.2014-1677

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2015-10-07 gostraight

#研究人员#

29 0
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2015-04-11 x35042875

AKI对心衰临床治疗意义重大，但依然需要研究检验其适用性

105 0
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2015-02-22 orthoW

不错的文章，学习了

98 0
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2015-02-17 chinayinhan

已阅

96 0
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2015-09-11 12498c32m68暂无昵称

#Endocrinology#

27 0
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2015-02-04 Desperardo1

好的?

97 0
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2015-02-03 223.104.5.**

Treg/Th17平衡对大部分自身免疫性疾病至关重要，但关键谁造成了这种失衡

94 0

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Endocrinology：研究人员发现预防I型糖尿病的方法

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