Circ Cardiovasc Imaging:左心房结构与年龄、性别、种族和心血管危险因素之间的关系如何?

2017-02-20 xing.T MedSci原创

由此可见,年龄、性别、种族和左室结构参数与左心房大小有关。重要的是,该研究为左心房体积指数提供了正常的参考值。

左心房大小是舒张功能的标志,并且与心房颤动和心血管结局有关。然而,没有大型的人群研究来测量左心房的结构。人口统计学和心血管危险因素与左心房大小的关系在很大程度上是未知的。最近,心血管领域权威杂志Circulation-Cardiovascular Imaging上发表了一篇研究文章,研究人员旨在明确左心房大小与人口因素、心脏结构和功能以及心血管危险因素之间的相关性。

研究人员通过心血管磁共振稳态自由进动序列和快速梯度回波电影长轴和短轴图像来评估左心房体积体,研究人员采用双平面和短轴图像检查了2576例无症状的MESA研究([动脉粥样硬化多民族研究],平均年龄为68.7岁,53%为妇女,白人占42.2%,华人占12%,黑人占24.5%,西班牙裔占21.2%)参与者。

在整个队列中,平均左心房体积指数为36.5×11.4mL/m2,无心血管危险因素的受试者(n=283)为35.5 mL/m2。多变量分析包括的调整因素有人口统计学、民族、心血管危险因素、血清学研究、社会经济地位、左心室结构和药物治疗。在调整后的分析中,年龄(β=0.2 mL/m2每年,P<0.0001)、男性(β=-4.2 mL/m2,P<0.0001)、肥胖(β=1.3 mL/m2,P<0.01)、舒张末期容积指数(β=0.4 mL/m2,P<0.0001)、美籍华人(β=-2.6 mL/m2,P<0.0001)以及西班牙(β=1.1 mL/m2,P<0.05)种族与左心房体积指数相关。糖尿病和吸烟与左心房体积指数无关。通过稳态自由进动序列测得的左心房体积要比心血管磁共振快速梯度回波电影测得的大3%(P<0.001)。

由此可见,年龄、性别、种族和左室结构参数与左心房大小有关。重要的是,该研究为左心房体积指数提供了正常的参考值。

原始出处:

Filip Zemrak,et al. Left Atrial Structure in Relationship to Age, Sex, Ethnicity, and Cardiovascular Risk Factors MESA (Multi-Ethnic Study of Atherosclerosis). Circ Cardiovasc Imaging. 2017. https://doi.org/10.1161/CIRCIMAGING.116.005379

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    2017-07-01 quxin068
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    2017-11-01 ylz8411
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    2017-02-22 sodoo
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