Eur Heart J:早产与女性长期心衰风险

2021-11-25 MedSci原创 MedSci原创

早产和早期足月产与HF的未来风险显著增加有关,早产和早足月产与HF的风险分别增加3倍和1.7倍,在调整其他孕妇和家庭因素后,这种危险仍然存在,并在分娩后40年仍然升高。

早产妇女未来患高血压和缺血性心脏病的风险更高,但心力衰竭(HF)的长期风险尚未明确,早产妇女在整个生命过程中心衰的长期风险如何?

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员在一个大型国家队列中评估了早产妇女的这些风险。

1973-2015年瑞典所有2201284名单胎分娩妇女均接受了住院或门诊HF诊断的随访,直至2015年。研究人员采用Cox回归计算了与妊娠持续时间相关的HF风险比(HR),并针对其他孕妇因素进行调整。共同兄弟姐妹分析以评估由共同的家族(遗传和/或环境)因素造成的混杂。

在4820万人次每年的随访中,19922名女性被诊断出患有HF(中位年龄:60.7岁)。在分娩后10年内,与足月产妇女(39-41周)相比,与早产妇女(胎龄:<37周)相关的HF调整后HR为2.96[95%置信区间(CI):2.48-3.53]。极早产儿妇女(22-27周)的分层HR为4.27(2.54-7.17),中度早产儿妇女(28-33周)为3.39(2.57-4.48),晚期早产儿妇女为2.70(2.19-3.32)(34-36周),早期足月产妇女(37-38周)为1.70(1.45-1.98)。这些HR下降但在分娩后10-19年(早产与足月:HR:2.19;95%CI:1.94-2.46)、20-29年(1.80;1.67-1.95)和30-43年期间仍持续升高(1.56;1.47-1.66),并且不能由共同的家庭因素所解释。

由此可见,早产和早期足月产与HF的未来风险显著增加有关,早产和早足月产与HF的风险分别增加3倍和1.7倍,在调整其他孕妇和家庭因素后,这种危险仍然存在,并在分娩后40年仍然升高。应将早产和早期足月产视为整个生命过程中HF的危险因素。

原始出处:

Casey Crump.et al.Pre-term delivery and long-term risk of heart failure in women: a national cohort and co-sibling study.European Heart Journal.2021.https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehab789/6438093?redirectedFrom=fulltext

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    2021-11-27 D-House

    学习了

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    2021-11-27 zhaojie88
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    2021-11-27 slcumt

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