Ann Rheum Dis:bDMARD药物获取的不平等及其如何影响各国疾病预后:METEOR登记结果

2018-07-08 xiangting MedSci原创

各国类风湿性关节炎患者的疾病活动性和bDMARD使用情况存在差异。国家bDMARD使用与疾病活动性水平之间的(负)关联是复杂的,受到许多因素的影响。

这项研究旨在全球范围内建立国家社会经济地位(SES)、测量的生物性疾病改善抗风湿药物(bDMARD)使用和疾病预后之间的关系。并评估处方和报销规则以及药物的一般获得是否与一个国家的bDMARD使用相关。

从METEOR数据库中提取至少有100名患者国家的疾病活动性和药物使用数据。按不同国家计算最终就诊时所有患者的平均疾病预后。至少向每个国家的两名风湿病学专家发送问卷,询问DMARD的价格、药物获取情况和处方报销的有效规定。

来自12个国家20379名患者的数据显示,国家SES与测量的疾病活动性(平均DAS28)呈正相关,但并不总与躯体功能(HAQ评分)相关。国家SES较低、bDMARD处方报销规则更严格和bDMARD负担能力更低与bDMARD使用率较低相关。使用bDMARD与疾病活动性呈负相关(虽然与躯体功能不相关),但这种关联最多为中度。

各国类风湿性关节炎患者的疾病活动性和bDMARD使用情况存在差异。国家bDMARD使用与疾病活动性水平之间的(负)关联是复杂的,受到许多因素的影响,其中包括但不限于国家的SES、bDMARD负担能力以及bDMARD的有效处方和报销规则。

原始出处:

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    2018-12-26 一闲
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    2018-07-10 whlxd
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    2018-07-08 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0