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Liver Int：与病毒性HCC患者相比，隐型肝癌患者的肿瘤更大，肿瘤分期愈晚，总体生存率较低

2018-05-14 MedSci MedSci原创

cryptogenicHCChepatitisBhepatitisChepatocellularcarcinoma
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与病毒性HCC患者相比，隐型肝癌患者的肝硬化患病率较低；隐型肝癌患者的肿瘤更大，肿瘤分期愈晚，总体生存率较低。

研究背景和目的：尽管乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染仍然是肝细胞癌(HCC)的主要危险因素，但HCC(尤其是非酒精性脂肪肝)的非病毒性病因越来越普遍。本研究的目的是比较隐性因素导致的HCC和病毒HCC的临床特点和存活率。

研究方法：本研究是一项回顾性队列研究。共纳入美国的2个三级中心和2004年至2014年期间，台湾的2个三级中心的3878例HCC患者。研究比较了潜在病因：隐源性病因(n = 696)、HBV (n = 1304)或HCV (n = 1878)的临床特征、治疗和生存率。

研究结果：研究结果表明，66.8%的不明原因引起的肝细胞癌患者，出现肝硬化；相比之下，74.7%的由HBV导致的肝癌患者(P = .001)，出现肝硬化；相比之下，85.9%的由HCV导致的肝癌患者(P < .001)，出现肝硬化。与病毒性病因导致的HCC相比，隐源性病因导致的肝癌，患者的肿瘤更大，肝癌分期愈晚。相比HBV-HCC患者的5年总体生存率为31.9%，HCV-HCC患者的5年总体生存率为27.7%，隐源性HCC的5年总体生存率为16.3% (logrank检验均为P < 0.001)。

研究结论：与病毒性HCC患者相比，隐型肝癌患者的肝硬化患病率较低；隐型肝癌患者的肿瘤更大，肿瘤分期愈晚，总体生存率较低。

原始出处：

Jun TW， Yeh ML， Yang JD， et al. More advanced disease and worse survival in cryptogenic compared to viral hepatocellular carcinoma. Liver Int， 2018， 38(5)， 895-902. doi： 10.1111/liv.13613.

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    2019-03-20 12498c32m79暂无昵称

    #肿瘤分期#

    0

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    2018-09-12 般若傻瓜

    #总体生存率#

    0

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    2018-12-28 howi

    #病毒性#

    0

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encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-15 zhu_jun9837

    #肝癌患者#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1740297, encodeId=52ac1e4029765, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Wed Mar 20 19:51:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668525, encodeId=d2c3166852574, content=<a href='/topic/show?id=2df452e4557' target=_blank style='color:#2F92EE;'>#总体生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52745, encryptionId=2df452e4557, topicName=总体生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-16 guoyibin

    #生存率#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1740297, encodeId=52ac1e4029765, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Wed Mar 20 19:51:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668525, encodeId=d2c3166852574, content=<a href='/topic/show?id=2df452e4557' target=_blank style='color:#2F92EE;'>#总体生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52745, encryptionId=2df452e4557, topicName=总体生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf0826335696, createdName=般若傻瓜, createdTime=Wed Sep 12 16:51:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986371, encodeId=663d19863e194, content=<a href='/topic/show?id=f3f1e0930ed' target=_blank style='color:#2F92EE;'>#病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70930, encryptionId=f3f1e0930ed, topicName=病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 28 19:51:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969015, encodeId=8fb4196901573, content=<a href='/topic/show?id=4dd7812e8f3' target=_blank style='color:#2F92EE;'>#肝癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81278, encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-16 jiyangfei

    #HCC#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1740297, encodeId=52ac1e4029765, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Wed Mar 20 19:51:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668525, encodeId=d2c3166852574, content=<a href='/topic/show?id=2df452e4557' target=_blank style='color:#2F92EE;'>#总体生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52745, encryptionId=2df452e4557, topicName=总体生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf0826335696, createdName=般若傻瓜, createdTime=Wed Sep 12 16:51:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986371, encodeId=663d19863e194, content=<a href='/topic/show?id=f3f1e0930ed' target=_blank style='color:#2F92EE;'>#病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70930, encryptionId=f3f1e0930ed, topicName=病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 28 19:51:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969015, encodeId=8fb4196901573, content=<a href='/topic/show?id=4dd7812e8f3' target=_blank style='color:#2F92EE;'>#肝癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81278, encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1740297, encodeId=52ac1e4029765, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Wed Mar 20 19:51:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668525, encodeId=d2c3166852574, content=<a href='/topic/show?id=2df452e4557' target=_blank style='color:#2F92EE;'>#总体生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52745, encryptionId=2df452e4557, topicName=总体生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf0826335696, createdName=般若傻瓜, createdTime=Wed Sep 12 16:51:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986371, encodeId=663d19863e194, content=<a href='/topic/show?id=f3f1e0930ed' target=_blank style='color:#2F92EE;'>#病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70930, encryptionId=f3f1e0930ed, topicName=病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 28 19:51:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969015, encodeId=8fb4196901573, content=<a href='/topic/show?id=4dd7812e8f3' target=_blank style='color:#2F92EE;'>#肝癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81278, encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1740297, encodeId=52ac1e4029765, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Wed Mar 20 19:51:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668525, encodeId=d2c3166852574, content=<a href='/topic/show?id=2df452e4557' target=_blank style='color:#2F92EE;'>#总体生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52745, encryptionId=2df452e4557, topicName=总体生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf0826335696, createdName=般若傻瓜, createdTime=Wed Sep 12 16:51:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986371, encodeId=663d19863e194, content=<a href='/topic/show?id=f3f1e0930ed' target=_blank style='color:#2F92EE;'>#病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70930, encryptionId=f3f1e0930ed, topicName=病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 28 19:51:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969015, encodeId=8fb4196901573, content=<a href='/topic/show?id=4dd7812e8f3' target=_blank style='color:#2F92EE;'>#肝癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81278, encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 131****2916

    不错的文章值得推荐

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1740297, encodeId=52ac1e4029765, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Wed Mar 20 19:51:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668525, encodeId=d2c3166852574, content=<a href='/topic/show?id=2df452e4557' target=_blank style='color:#2F92EE;'>#总体生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52745, encryptionId=2df452e4557, topicName=总体生存率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bf0826335696, createdName=般若傻瓜, createdTime=Wed Sep 12 16:51:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986371, encodeId=663d19863e194, content=<a href='/topic/show?id=f3f1e0930ed' target=_blank style='color:#2F92EE;'>#病毒性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70930, encryptionId=f3f1e0930ed, topicName=病毒性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Dec 28 19:51:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969015, encodeId=8fb4196901573, content=<a href='/topic/show?id=4dd7812e8f3' target=_blank style='color:#2F92EE;'>#肝癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81278, encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue May 15 16:51:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256655, encodeId=ac0e125665595, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259503, encodeId=aba81259503bb, content=<a href='/topic/show?id=2200854517' target=_blank style='color:#2F92EE;'>#HCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8545, encryptionId=2200854517, topicName=HCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Wed May 16 11:51:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315136, encodeId=c684315136c1, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:55 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315135, encodeId=653e315135da, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 14 22:57:14 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315129, encodeId=0253315129f5, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:36:50 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315112, encodeId=6a933151125d, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 14 21:42:51 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 王秀

    学习了.涨知识了!

    0

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