Oncogene：地塞米松对肿瘤免疫治疗有害 OR 有益？上海瑞金医院于颖彦教授告诉您答案

2021-07-02 瑞金医院瑞金医院发表于威斯康星

2021年七一前夕，附属瑞金医院消化外科研究所于颖彦等在《Oncogene》在线发表了题为 “Dexamethasone suppresses immune evasion by indu

2021年七一前夕，附属瑞金医院消化外科研究所于颖彦等在《Oncogene》在线发表了题为 “Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways”（地塞米松通过GR/STAT3下调PD-L1与IDO1双通路从而抑制肿瘤免疫逃逸）的研究成果。 T细胞耗竭是肿瘤免疫逃逸的一个关键因素，亟待开发针对肿瘤的免疫治疗新策略。本研究旨在针对T细胞耗竭寻找潜在化合物，以期提高对免疫检查点抑制剂治疗的反应性。研究首先对不同免疫逃逸能力肿瘤的基因转录组数据进行分析获得差异表达基因，再通过药物重定位CMap平台对差异表达基因进行反向匹配分析，获得具有提高免疫检查点抑制剂反应性的潜在候选化合物。再通过基因集富集分析、LDH释放、染色质免疫沉淀和免疫共沉淀等体外实验探讨分子机制。该研究借助了人源性类器官模型和人源化小鼠异种移植瘤模型，开展候选化合物的疗效验证研究。通过对25种具有调控肿瘤免疫逃逸潜能的候选化合物筛选发现，地塞米松在多种肿瘤的

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#插入话题

插入图片

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2021-07-20 ms2694732865965676

#上海瑞金医院#

34 0
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2022-05-13 cy0324

#Gene#

27 0
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2021-07-08 SR~young海东

谈癌色变

45 0
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2021-07-04 zsyan

#Oncogene#

42 0
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2021-07-04 lshanp

拜读学习中

50 0
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2021-07-03 145e3356m81暂无昵称

不错

0 0
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2021-07-02 SR~young海东

关乎医药

40 0

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Oncogene：地塞米松对肿瘤免疫治疗有害 OR 有益？上海瑞金医院于颖彦教授告诉您答案

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