AJG:社会经济地位对于炎症性肠病患者的预后影响

2020-12-27 MedSci原创 MedSci原创

炎性肠病(IBD)包括克罗恩氏病(CD)和溃疡性结肠炎(UC),这些疾病通常出现在青春期和成年早期,IBD主要通过免疫调节药物治疗,这种药物有时可能会引起严重的不良反应。

      炎性肠病(IBD)包括克罗恩氏病(CD)和溃疡性结肠炎(UC),这些疾病通常出现在青春期和成年早期,IBD主要通过免疫调节药物治疗,这种药物有时可能会引起严重的不良反应,并且最终需要通过手术进行治疗。对于日常生活活动和生活质量的影响以及社会成本,IBD会给个人带来巨大的经济成本。了解哪些人患疾病并发症的风险更高,可以帮助他们在疾病过程中尽早集中适当的资源,从而降低以后对个人和社会的成本。

 

      较低的社会经济地位(LSS)被认为是许多状况下结局恶化的危险因素,人们通常认为,财政不平等会加剧健康不平等。但是,不良的健康预后不仅取决于收入,童年时期不利的社会环境,例如在低收入家庭成长成年后,与代谢风险相关的疾病的风险显著上升。目前,与慢性免疫介导的疾病,尤其是IBD,收入相对于其他不良社会经历的作用尚未得到充分的研究。因此,在以人群为基础的炎症性肠病(IBD)队列中,本项研究旨在确定较低的社会经济地位(LSS)是否会影响IBD的预后。

 

      研究人员收集了1995年4月1日至2018年3月31日间9298名患有IBD的患者。他们的数据与另外2个当地数据库关联,一个数据库确定了所有获得就业和收入援助的人,另一个数据库确定了所有与儿童和家庭服务联系的人。区域级社会经济地位是由一个因素得分定义的,该因子得分包括平均家庭收入,单亲家庭,失业率和高中文化程度。

 

 

      研究人员将LSS高的患者与LSS低的患者进行比较,发现LSS低的患者每年门诊就诊的比率有所增加([RR] = 1.10,95%置信区间[CI] = 1.06-1.13),住院治疗也更频繁(RR = 1.38,95 %CI = 1.31-1.44),重症监护病房入院更高(RR = 1.94,95%CI = 1.65–2.27),使用糖皮质激素> 2,000 mg/年(RR = 1.12,95%CI = 1.03-1.21)和死亡(危险比1.53,95%CI = 1.36–1.73)也更加严重。麻醉品(RR = 2.17,95%CI = 2.01–2.34)和精神药物的使用(RR = 1.98,95%CI = 1.84–2.13)有所增加。同时研究人员还发现LSS对克罗恩病患者的影响要大于溃疡性结肠炎患者。

 

      为什么患有IBD的较低的LSS患者的结局会更糟?这可能反映出门诊医疗保健利用率下降,或者由于任何原因,LSS较低的患者可能拥有较差的药物依从性等原因。如果LSS较低的患者不太主动或在活动性疾病早期不进行干预,那么他们就不太可能坚持用药,并且不太可能接受放射学诊断检查,那么他们的结局可能会更差,反应在手术增加和ICU住院人数增加以及其他人所显示的死亡率增加所体现。

 

      因此,研究人员最后说道在许多健康状况下,较低的社会经济地位被认为是导致不良后果的危险因素,在IBD中也是这样。

 

 

原始出处:

Bernstein, Charles N. et al. Social Determinants of Outcomes in Inflammatory Bowel Disease. The American Journal of Gastroenterology.2020.

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2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911304, encodeId=6ecd9113044c, content=社会经济地位对于炎症性肠病患者的预后影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:15:34 CST 2020, time=2020-12-27, status=1, ipAttribution=)]
    2020-12-30 124764c3m24(暂无昵称)

    哈哈这个有趣

    0

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2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911304, encodeId=6ecd9113044c, content=社会经济地位对于炎症性肠病患者的预后影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:15:34 CST 2020, time=2020-12-27, status=1, ipAttribution=)]
    2020-12-29 Jessica

    财政不平等会加剧健康不平等。较低的社会经济地位被认为是导致不良后果的危险因素,在IBD中也是这样。

    0

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  8. 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  9. 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2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911304, encodeId=6ecd9113044c, content=社会经济地位对于炎症性肠病患者的预后影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sun Dec 27 19:15:34 CST 2020, time=2020-12-27, status=1, ipAttribution=)]
    2020-12-27 oo902

    社会经济地位对于炎症性肠病患者的预后影响

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