Biomed Res Int:Semaphorin3A/Neuropilin-1信号轴在根尖牙周炎中的表达降低

2018-03-01 MedSci MedSci原创

根尖周炎(apical periodontitis,AP)是一种慢性感染性牙髓病,伴随着根尖周围的骨质破坏。 Semaphorin3A(Sema3A)和neuropilin-1(Nrp1)是骨代谢中的一对免疫调节剂。在本研究中,我们首先研究了Sema3A/Nrp1在根尖牙周炎中的表达模式及其与骨破坏的相关性。使用大鼠动物模型,我们分析了牙髓暴露后第0,7,14,21,28和35天的下颌骨破坏水平和

根尖周炎(apical periodontitis,AP)是一种慢性感染性牙髓病,伴随着根尖周围的骨质破坏。 Semaphorin3A(Sema3A)和neuropilin-1(Nrp1)是骨代谢中的一对免疫调节剂。在本研究中,我们首先研究了Sema3A/Nrp1在根尖牙周炎中的表达模式及其与骨破坏的相关性。

使用大鼠动物模型,我们分析了牙髓暴露后第0,7,14,21,28和35天的下颌骨破坏水平和Sema3A/Nrp1的表达。另外,获得来自根尖牙周炎患者的临床样品以分析Sema3A/Nrp1的表达。

结果显示,骨破坏水平从第7天扩大到第35天。Sema3A/Nrp1的阳性细胞数量和mRNA表达水平从第7天到第35天明显降低,与骨破坏呈负相关。此外,与对照组临床样品相比,AP组中Sema3A/Nrp1的表达降低。

总之,在根尖周病灶中观察到Sema3A/Nrp1的表达下降,并且可能参与了根尖周围区域的骨吸收,这表明Sema3A/Nrp1可能导致根尖牙周炎的病理发展。

原始出处:

Lin Y, Xing Q, et al., Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis. Biomed Res Int. 2017;2017:8724503. doi: 10.1155/2017/8724503. Epub 2017 Dec 31.

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    2018-11-04 chg121
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    2018-09-21 sunylz
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    2018-03-03 fengyi812
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    2018-03-01 changjiu

    学习学习谢谢

    0

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    2018-03-01 1e0f8808m18(暂无匿称)

    学习了.好文章.

    0