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BRAIN：REM睡眠行为障碍和随后的帕金森氏表型

2020-12-31 MedSci原创 MedSci原创

帕金森氏；表型
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特发性快速眼动睡眠行为障碍（RBD）现在被认为是α-突触核蛋白病的早期表现。

特发性快速眼动睡眠行为障碍（RBD）现在被认为是α-突触核蛋白病的早期表现。越来越多的实验研究表明，操纵性病变或背侧外侧被膜核（在人类中也称为蓝小核下核）内的神经元失活可以诱导动物的RBD样行为。由于当前的RBD动物模型不是基于α型突触核蛋白病建立的，因此它们不代表特发性RBD的病理学底物，因此无法建模为帕金森氏病的表型转化。因此，本研究的目的是建立一种基于α-突触核蛋白病的RBD动物模型，该模型具有转化为帕金森病的潜力。为此，研究人员首先在野生型C57BL / 6J小鼠中确定了背外侧皮下被膜核的功能神经解剖位置，然后基于此确定的核通过概括RBD样行为来验证其功能。接下来，将预先形成的α-突触核蛋白原纤维注射入背侧睑板下核，并在这些小鼠中进行常规多导睡眠图记录以及帕金森氏行为和组织病理学研究。结果表征了了小鼠中的RBD样行为，并进一步表明，在肩背外侧被膜核内发现的α-突触核蛋白病和神经元变性是神经病理学的底物。随后的帕金森氏症行为研究表明，基于α突触核蛋白病的RBD小鼠模型不是平稳的，但可以进一步发展为表现出帕金森氏症的运动功能障碍，抑郁样障碍，嗅觉功能障碍和胃肠道运动障碍。相应地，本研究确定了黑质致密部，嗅球，肠神经丛和迷走神经背运动核中的α-突触核蛋白病理，这可能是小鼠帕金森氏症表现的基础。总而言之，本研究建立了一个基于α突触核蛋白病的新型RBD小鼠模型，并在该动物模型中进一步证明了RBD向帕金森病的表型转化。

原文出处：

Yan Shen, Wen-Bo Yu, Bo Shen, https://academic.oup.com/brain/article-abstract/143/11/3374/5973939?redirectedFrom=fulltext.

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    2021-08-10 tongyongming

    #REM#

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    2021-06-17 12498cb5m23暂无昵称

    #行为障碍#

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    2021-01-02 tastas

    #表型#

    0