BMC Oral Health:慢性牙周炎和2型糖尿病患者血清和唾液中铁蛋白和铁调素水平

2018-05-07 MedSci MedSci原创

铁紊乱和铁调素异常表达在许多疾病中发挥重要作用,但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚。我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平。 从88名参与者中收集血清和未刺激的全唾液样品,根据是否存在CP或T2DM将其分为4组。记录人口统计学和一般健康参数。记录全口临床牙周参数,包括探诊深度、临床附着丧失、出血指数和菌斑指数。化学发光微粒免疫

铁紊乱和铁调素异常表达在许多疾病中发挥重要作用,但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚。我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平。

从88名参与者中收集血清和未刺激的全唾液样品,根据是否存在CP或T2DM将其分为4组。记录人口统计学和一般健康参数。记录全口临床牙周参数,包括探诊深度、临床附着丧失、出血指数和菌斑指数。化学发光微粒免疫分析和酶联免疫吸附试验分别检测血清和唾液中的铁蛋白和铁调素浓度。

结果显示,CP组和CP组血清铁蛋白和铁调素水平高于对照组(P <0.05)。血清hepcidin和血清铁蛋白呈线性相关(P <0.001)。2型糖尿病组血清铁调素/铁蛋白值明显低于2型糖尿病组和对照组。此外,CP组和T2DM组唾液铁蛋白水平均高于对照组(P <0.05)。唾液铁蛋白与血清铁蛋白呈正相关(P = 0.017)。唾液中铁调素浓度相对较低。

这些结果提示2型糖尿病患者存在铁超载和铁调素不足。唾液铁蛋白可能为身体铁负荷提供参考。

原始出处:

Lin-Na Guo, Yan-Zong Yang, et al., Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2018; 18: 63. doi:  10.1186/s12903-018-0524-4

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    2018-05-21 小几洁
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encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312955, encodeId=f5f1312955f0, content=铁紊乱和铁调素异常表达在许多疾病中发挥重要作用.但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚.我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 07 22:19:31 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
    2019-04-22 shizhenshan
  4. 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target=_blank style='color:#2F92EE;'>#铁调素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96564, encryptionId=fe70965643d, topicName=铁调素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368660, encodeId=0761136866068, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), 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createdName=liuyong2982, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474496, encodeId=200e14e4496ef, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621720, encodeId=942b1621e20da, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312955, encodeId=f5f1312955f0, content=铁紊乱和铁调素异常表达在许多疾病中发挥重要作用.但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚.我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 07 22:19:31 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
  5. 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target=_blank style='color:#2F92EE;'>#铁调素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96564, encryptionId=fe70965643d, topicName=铁调素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368660, encodeId=0761136866068, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383437, encodeId=f3a2138343edd, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450867, encodeId=5681145086eb0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474496, encodeId=200e14e4496ef, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621720, encodeId=942b1621e20da, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312955, encodeId=f5f1312955f0, content=铁紊乱和铁调素异常表达在许多疾病中发挥重要作用.但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚.我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 07 22:19:31 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
  6. 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target=_blank style='color:#2F92EE;'>#铁调素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96564, encryptionId=fe70965643d, topicName=铁调素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368660, encodeId=0761136866068, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383437, encodeId=f3a2138343edd, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450867, encodeId=5681145086eb0, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474496, encodeId=200e14e4496ef, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621720, encodeId=942b1621e20da, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312955, encodeId=f5f1312955f0, content=铁紊乱和铁调素异常表达在许多疾病中发挥重要作用.但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚.我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 07 22:19:31 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
  7. 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target=_blank style='color:#2F92EE;'>#铁调素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96564, encryptionId=fe70965643d, topicName=铁调素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9c94141, createdName=liuquanmn, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368660, encodeId=0761136866068, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), 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encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Wed May 09 10:19:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312955, encodeId=f5f1312955f0, content=铁紊乱和铁调素异常表达在许多疾病中发挥重要作用.但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚.我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 07 22:19:31 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
    2018-05-07 有备才能无患

    铁紊乱和铁调素异常表达在许多疾病中发挥重要作用.但在慢性牙周炎(CP)和2型糖尿病(T2DM)中的作用仍不清楚.我们旨在评估患有或不患有T2DM的CP患者的血清和唾液中的铁蛋白和铁调素水平.

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