Chest:支气管内超声引导下经支气管活检后感染并发症的危险因素

2020-03-10 xing.T MedSci原创

由此可见,病灶CT表现为空化、LDAs以及经支气管镜观察到的支气管狭窄是EBUS-GS-TBB术后感染的危险因素。在该队列中,预防性抗生素未能预防EBUS-GS-TBB感染并发症。

支气管内超声引导下通过导管鞘经支气管穿刺活检术(EBUS-GS-TBB)后的感染性并发症严重,可能会延迟或改变预定的后续治疗。近日,呼吸领域权威杂志chest上发表了一篇研究文章,该研究的目的是明确EBUS-GS-TBB术后感染的危险因素。

研究人员回顾了2013年1月至2017年12月在藤田健康大学医院连续就诊的1045例因周围性肺部病变接受EBUS-GS-TBB的患者医疗记录。研究人员评估了EBUS-GS-TBB后感染性并发症的危险因素如下:病人特征(年龄、并发症)、病灶大小、目标病变的CT特征(瘤内低密度面积(LDAs)、空洞)、支气管镜检查观察到支气管狭窄和EBUS-GS-TBB之前的实验室检查数据(白细胞计数和c反应蛋白浓度)。

47例患者发生感染并发症(肺炎24例,瘤内感染14例,肺脓肿3例,胸膜炎3例,脓胸3例),其中并发症导致癌症治疗延误13例,癌症治疗取消7例,死亡3例。多因素分析显示,EBUS-GS-TBB术后的感染并发症与瘤内LDAs (P<0.001)、经支气管镜检查发现的支气管狭窄(P<0.001)、空洞(P=0.007)密切相关。感染组共13例患者给予预防性抗生素治疗。倾向匹配分析未发现预防性抗生素治疗在预防EBUS-GS-TBB感染方面的显著益处。

由此可见,病灶CT表现为空化、LDAs以及经支气管镜观察到的支气管狭窄是EBUS-GS-TBB术后感染的危险因素。在该队列中,预防性抗生素未能预防EBUS-GS-TBB感染并发症。

原始出处:

Tomohide Souma,et al.Risk factors of infectious complications after endobronchial ultrasound-guided transbronchial biopsy.chest.2020.https://doi.org/10.1016/j.chest.2020.02.025

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    2020-04-27 丁鹏鹏
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    2021-01-06 Smile2680
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