CLIN CANCER RES：结肠癌淋巴结转移呈现多克隆性

2018-05-18 MedSci MedSci原创

近期的研究强调了肿瘤中亚克隆的存在。对包括结直肠癌在内的绝大部分上皮类肿瘤来说，淋巴结通常是转移的第一站。CLIN CANCER RES近期发表了一篇文章，评估原发肿瘤和淋巴结中的结直肠癌亚克隆关系，从而研究结直肠癌淋巴结转移的遗传起源。

近期的研究强调了肿瘤中亚克隆的存在。对包括结直肠癌在内的绝大部分上皮类肿瘤来说，淋巴结通常是转移的第一站。CLIN CANCER RES近期发表了一篇文章，评估原发肿瘤和淋巴结中的结直肠癌亚克隆关系，从而研究结直肠癌淋巴结转移的遗传起源。

研究共分析了来自7例结直肠癌的33例标本，包括原发肿瘤的2或3个独立区域以及每个肿瘤相匹配的1到4个淋巴结，标本进行二代全基因组DNA测序，Affymetrix OncoScan SNP arrays，和靶向深度确认测序。对原发肿瘤和匹配的淋巴结样本进行单核苷酸多态性（SNP）和拷贝数分析，从而描述出淋巴结转移的异质性及突变起源。使用PyClone计算方法定义每个肿瘤的亚克隆情况。使用CITUP方法推断亚克隆之间的系统进化关系。研究结果表明，任何患者的所有样本中突变和拷贝数改变均存在很大的异质性。对每个患者来说，原发肿瘤部位和匹配的淋巴结转移都是多克隆的，且不同淋巴结之间的克隆群不同。在某些患者中，特定淋巴结中的肿瘤细胞族群来源于原发肿瘤的多个不同区域。

文章最后认为，结直肠癌淋巴结转移时，随着时间的改变，转移部位的肿瘤来源于原发肿瘤的多次播散。

原始出处：

Peter J.Ulintz,Joel K.Greenson,et al.Lymph Node Metastases in Colon Cancer Are Polyclonal.CLIN CANCER RES.May 2018 doi:10.1158/1078-0432.CCR-17-1425

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2018-11-02 aids221

#克隆#

21 0
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2018-06-06 蔬菜

学习了.研究技术非常高精尖!

67 0
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2018-05-20 sodoo

#淋巴结#

36 0
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2018-05-20 snf701207

#淋巴结转移#

0 0
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2018-05-18 131****2916

不错的文章值得推荐

80 0
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2018-05-18 12225669m29暂无昵称

学习

68 0
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2018-05-18 王秀

学习了.涨知识了!

74 0

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