DIABETOLOGIA:血浆神经酰胺与内脏肥胖,胰岛素抵抗和2型糖尿病发展的关系

2018-12-01 MedSci MedSci原创

神经酰胺是临床前研究中有助于胰岛素抵抗的鞘脂类物质。本研究假设血浆神经酰胺与多种族群体中的体脂分布,胰岛素抵抗和2型糖尿病相关。 在没有2型糖尿病的达拉斯心脏研究中,共有1557名参与者通过液相色谱 - 质谱法测量代谢生物标志物,MRI和血浆神经酰胺的脂肪库。7年后评估糖尿病结果。研究人员分析了基线时神经酰胺对身体脂肪和胰岛素抵抗的关联以及神经酰胺与糖尿病后果的相关性。 结果显示,该队

神经酰胺是临床前研究中有助于胰岛素抵抗的鞘脂类物质。本研究假设血浆神经酰胺与多种族群体中的体脂分布,胰岛素抵抗和2糖尿病相关。

在没有2糖尿病的达拉斯心脏研究中,共有1557名参与者通过液相色谱 - 质谱法测量代谢生物标志物,MRI和血浆神经酰胺的脂肪库。7年后评估糖尿病结果。研究人员分析了基线时神经酰胺对身体脂肪和胰岛素抵抗的关联以及神经酰胺与糖尿病后果的相关性。

结果显示,该队列的平均年龄为43岁,女性为58%,黑人为45%,平均BMI28 kg / m 2。总胆固醇水平与所有神经酰胺相关,但较高的三酰基甘油和较低的HDL-胆固醇和脂联素仅与饱和脂肪酸链神经酰胺相关(p  <0.0003)。调整临床特征和总体脂肪后,内脏脂肪组织与饱和脂肪酸神经酰胺呈正相关(每SDβ  = 0.160.18),与多不饱和脂肪酸神经酰胺呈负相关(β  = -0.14-0.16p所有人均<0.001。下体皮下脂肪显示出与内脏脂肪相反的模式。HOMA-IR与饱和度(β  = 0.080.09p  <0.001)呈正相关,与多不饱和神经酰胺呈负相关(β  = -0.06-0.07p  <0.05)。在调整临床因素后,神经酰胺与2型糖尿病无关。

研究表明,血浆神经酰胺与功能失调性肥胖的代谢和成像指标显示出复杂的生物学关系。关于神经酰胺在代谢功能障碍的共同途径中的作用需要对内脏肥胖和胰岛素抵抗进一步研究。

原始出处:

Ian J. Neeland, Shruti Singh,Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

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    2019-03-01 baoya
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1935634, encodeId=8dc11935634c7, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Wed Mar 20 09:20:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638884, encodeId=a56d163888485, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 16 02:20:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750027, encodeId=e8121e50027a9, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Mar 01 15:20:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760916, encodeId=6cab1e60916c8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 08 19:20:00 CST 2019, time=2019-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510745, encodeId=96211510e4529, content=<a href='/topic/show?id=38ebe459755' target=_blank style='color:#2F92EE;'>#神经酰胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74597, encryptionId=38ebe459755, topicName=神经酰胺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c2a10230680, createdName=xugc, createdTime=Mon Dec 03 02:20:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042077, encodeId=49c510420e7d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Dec 01 14:20:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354188, encodeId=0e5b354188f4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Dec 01 13:51:57 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354178, encodeId=218b3541e824, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Dec 01 12:29:36 CST 2018, time=2018-12-01, status=1, ipAttribution=)]
    2018-12-03 xugc
  6. [GetPortalCommentsPageByObjectIdResponse(id=1935634, encodeId=8dc11935634c7, content=<a href='/topic/show?id=e08030504e4' target=_blank style='color:#2F92EE;'>#内脏肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30504, encryptionId=e08030504e4, topicName=内脏肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Wed Mar 20 09:20:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638884, encodeId=a56d163888485, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 16 02:20:00 CST 2019, time=2019-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750027, encodeId=e8121e50027a9, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Mar 01 15:20:00 CST 2019, time=2019-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760916, encodeId=6cab1e60916c8, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 08 19:20:00 CST 2019, time=2019-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510745, encodeId=96211510e4529, content=<a href='/topic/show?id=38ebe459755' target=_blank style='color:#2F92EE;'>#神经酰胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74597, encryptionId=38ebe459755, topicName=神经酰胺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c2a10230680, createdName=xugc, createdTime=Mon Dec 03 02:20:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042077, encodeId=49c510420e7d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Dec 01 14:20:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354188, encodeId=0e5b354188f4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Dec 01 13:51:57 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354178, encodeId=218b3541e824, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Dec 01 12:29:36 CST 2018, time=2018-12-01, status=1, ipAttribution=)]
    2018-12-01 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2018-12-01 医者仁心5538

    学习了

    0

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    2018-12-01 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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