ACS子刊:研究发现五味子提取物PET2治疗哮喘的主要机制

2022-04-28 小文子 MedSci原创

研究明确了五味子提取物的亚组分PET2可有效缓解OVA诱导的哮喘小鼠气道炎症。

五味子是一种广泛的可食用和药用资源,其提取物对哮喘小鼠气道炎症有较好的抑制作用。五味子提取物EtOH的活性组分主要集中在PET的可溶性组分中,去除PET组分中的Szn、Sol B和Ssn B后,亚组分PET2在体外实验模型中表现出比Szn、Sol B和Ssn B更强的抗炎作用。

Journal of Agricultural and Food Chemistry杂志的一项研究使用卵清蛋白(OVA)诱导的过敏性哮喘小鼠模型评估PET2的抗炎作用,通过UPLC-Q-TOF/MS表征PET2的化学成分,阐明其抗炎活性成分,并探讨PET2抗哮喘的潜在机制。

研究人员对实验组小鼠在第0、7和14天腹腔注射200 μL OVA/ alum(磷酸盐缓冲生理盐水稀释,PBS)以致敏,对照小鼠腹腔注射等体积PBS。结合网络药理学分析和体外实验进行分析。并使用IL-4/TNF-α诱导的BEAS-2B细胞模型,进一步验证其活性成分的抗炎作用。

研究发现,PET2在IL-4/ TNF-α刺激的BEAS-2B细胞中表现出明显的抗炎作用。同时,在卵清蛋白(OVA)诱导的过敏性哮喘小鼠模型中,PET2处理(200和400mg/kg)对减轻气道炎性细胞浸润和降低血清Th2相关细胞因子有明显作用。此外,模型组血清超氧化物歧化酶(SOD)水平明显降低,丙二醛(MDA)含量明显升高(P<0.01)。PET2治疗可提高哮喘小鼠SOD水平,降低MDA水平。研究人员发现,PET2的有效抗哮喘特性可能归因于6种化合物。潜在机制可能涉及Fc epsilon RI、T细胞受体和Jak-STAT信号通路。

研究明确了五味子提取物的亚组分PET2可有效缓解OVA诱导的哮喘小鼠气道炎症,网络药理学预测和实验证实其平喘作用归因于PET2中所含的6种抗炎化合物,为其抗哮喘科学利用提供理论依据。

原文出处:

Bin Li, Qi Xiao, Jiushi Liu,et al,Chemical Characterization and Potential Mechanism of the Anti-Asthmatic Activity of a Subfraction from Schisandra chinensis Fruit Extract, Journal of Agricultural and Food Chemistry, 2022,https://doi.org/10.1021/acs.jafc.2c01034.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1753641, encodeId=71d41e53641d6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Sun Aug 14 10:42:29 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729518, encodeId=80221e2951863, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 08 17:42:29 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279376, encodeId=957f12e93767a, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331212, encodeId=3ef4133121230, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214874, encodeId=5ba812148e4f4, content=<a href='/topic/show?id=c11924159b6' target=_blank style='color:#2F92EE;'>#五味子#</a>提取物PET2治疗<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>,但是PET2应用的浓度达到200mg/kg,基本可以判断没有任何临床实际意义,无法成为治疗性药物了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24159, encryptionId=c11924159b6, topicName=五味子), TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 26 21:45:09 CST 2022, time=2022-04-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1753641, encodeId=71d41e53641d6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Sun Aug 14 10:42:29 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729518, encodeId=80221e2951863, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 08 17:42:29 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279376, encodeId=957f12e93767a, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331212, encodeId=3ef4133121230, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214874, encodeId=5ba812148e4f4, content=<a href='/topic/show?id=c11924159b6' target=_blank style='color:#2F92EE;'>#五味子#</a>提取物PET2治疗<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>,但是PET2应用的浓度达到200mg/kg,基本可以判断没有任何临床实际意义,无法成为治疗性药物了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24159, encryptionId=c11924159b6, topicName=五味子), TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 26 21:45:09 CST 2022, time=2022-04-26, status=1, ipAttribution=)]
    2023-04-08 feather89
  3. [GetPortalCommentsPageByObjectIdResponse(id=1753641, encodeId=71d41e53641d6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Sun Aug 14 10:42:29 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729518, encodeId=80221e2951863, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 08 17:42:29 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279376, encodeId=957f12e93767a, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331212, encodeId=3ef4133121230, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214874, encodeId=5ba812148e4f4, content=<a href='/topic/show?id=c11924159b6' target=_blank style='color:#2F92EE;'>#五味子#</a>提取物PET2治疗<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>,但是PET2应用的浓度达到200mg/kg,基本可以判断没有任何临床实际意义,无法成为治疗性药物了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24159, encryptionId=c11924159b6, topicName=五味子), TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 26 21:45:09 CST 2022, time=2022-04-26, status=1, ipAttribution=)]
    2022-04-28 yaanren
  4. [GetPortalCommentsPageByObjectIdResponse(id=1753641, encodeId=71d41e53641d6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Sun Aug 14 10:42:29 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729518, encodeId=80221e2951863, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 08 17:42:29 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279376, encodeId=957f12e93767a, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331212, encodeId=3ef4133121230, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214874, encodeId=5ba812148e4f4, content=<a href='/topic/show?id=c11924159b6' target=_blank style='color:#2F92EE;'>#五味子#</a>提取物PET2治疗<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>,但是PET2应用的浓度达到200mg/kg,基本可以判断没有任何临床实际意义,无法成为治疗性药物了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24159, encryptionId=c11924159b6, topicName=五味子), TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 26 21:45:09 CST 2022, time=2022-04-26, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1753641, encodeId=71d41e53641d6, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Sun Aug 14 10:42:29 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729518, encodeId=80221e2951863, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 08 17:42:29 CST 2023, time=2023-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279376, encodeId=957f12e93767a, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331212, encodeId=3ef4133121230, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Thu Apr 28 05:42:29 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214874, encodeId=5ba812148e4f4, content=<a href='/topic/show?id=c11924159b6' target=_blank style='color:#2F92EE;'>#五味子#</a>提取物PET2治疗<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>,但是PET2应用的浓度达到200mg/kg,基本可以判断没有任何临床实际意义,无法成为治疗性药物了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24159, encryptionId=c11924159b6, topicName=五味子), TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 26 21:45:09 CST 2022, time=2022-04-26, status=1, ipAttribution=)]
    2022-04-26 病毒猎手

    #五味子#提取物PET2治疗#哮喘#,但是PET2应用的浓度达到200mg/kg,基本可以判断没有任何临床实际意义,无法成为治疗性药物了。

    0

相关资讯

上海东方医院护士不幸去世,医院发布声明:深感痛心!

南院急诊部因疫情防控需要,正暂时关闭。

JACIP:Dupilumab单抗显示对特应性皮炎、哮喘、鼻窦炎并鼻息肉的快速反应

Dupilumab被批准用于治疗某些中到重度特应性皮炎(AD)、中到重度哮喘和慢性鼻-鼻窦炎并鼻息肉患者。本文评估了139名患者在接受dupilumab治疗中症状和临床相关结果有意义的变化。

Radiology:让我们通过3He MRI重新认识CT上发现的粘液栓!

通气异质性是哮喘的基础病理生理特征,可通过超极化氦3(3He)MRI观察到的通气障碍反映。

不敢用药,怀孕的哮喘患者怎么办?

30岁女性,目前怀孕13周。最近1个月哮喘反复发作,自己能听到夜间有喘鸣声,有时胸口闷,像有东西压住,需要坐起来用力呼吸,白天好转,能比较正常活动,有时咳嗽,干咳无痰,晚上多一些。

Allergy Asthma Immunol Res:特应性皮炎、哮喘和过敏性鼻炎患者的生活质量和心理健康状况如何?

近日,来自韩国天主教大学的研究人员调查了过敏性疾病患者与非过敏性对照组人群的心理健康状况和生活质量。相关研究结果发表在Allergy Asthma Immunol Res期刊上。

Lancet子刊:小气道疾病与哮喘结局显著相关,ATLANTIS前瞻性队列研究数据给出答案

为了更好的治疗哮喘患者,应评估小气道功能、大气道功能和生物标记物,作为哮喘表型的一部分,以更好地了解患者预后不良的风险。