Arthritis Rheumatol:区分中轴型脊柱关节炎与其他原因臀部/骨盆疼痛的骶髂关节MRI病变

2019-07-22 xiangting MedSci原创

BME和脂肪病变在axSpA中最为明显,但也发生在其他组,特别是产后疼痛的女性。

这项研究旨在评估不同类型的骶髂关节(SIJ)病变磁共振成像(MRI)是否可以区分中轴型脊柱关节炎(axSpA)与其他原因的臀部/骨盆疼痛,其中包括产后妇女和健康人。

这项前瞻性横断面研究纳入204名参与者:axSpA(n=41)、腰椎间盘突出症患者(n=25)、伴产后(最近16个月内生育)臀部/骨盆疼痛的女性(n=46)、无产后臀部/骨盆疼痛女性(n=14)、清洁工(n=26)、长跑运动员(n=23)和没有疼痛的健康男性(n=29)。参与者接受临床检查和MRI,根据加拿大脊柱关节炎研究联盟(SPARCC)SIJ炎症和结构评分对MRI进行盲法评估(两名阅片者)。评分"阈值"定义为高于特定阈值的分数。初步分析基于阅片者对存在病变的一致性("一致性读数")。计算敏感性、特异性、阳性/阴性预测值。

MRI SIJ强直和回填仅见于axSpA患者(32%/37%),而所有非axSpA组均出现骨髓水肿(BME 3-39%)和脂肪病变(4-14%)。侵蚀仅存在于axSpA(阈值评分> 1:61%/阈值评分> 4:34%)和产后疼痛女性(9%/2%)。SPARCC BME≥5仅见于axSpA(56%)和产后疼痛女性(24%),而在高阈值水平几乎所有组都存在脂肪病变,尽管很少。38名既往生育(平均9.7年前)来自对照组的女性中,2名(5%)有BME,没有侵蚀或脂肪病变,BME均不≥4。

BME和脂肪病变在axSpA中最为明显,但也发生在其他组,特别是产后疼痛的女性。超过特定阈值的侵蚀、回填和强直对axSpA具有高度特异性。

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    2019-10-26 Homburg
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    2019-07-24 lmm397
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    2019-07-24 zhaojie88
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