Biol Psychiat:发炎的星形胶质细胞也能导致自闭症

2017-10-20 佚名 大话精神

加州大学圣地亚哥医学院(University of California San Diego School of Medicine)的研究人员与来自巴西的同事们建立了一个由自闭症谱系障碍儿童(ASD)衍生的神经元与星形胶质细胞之间相互作用的模型,他们说,星形胶质细胞的先天炎症似乎在某种形式的疾病中会导致神经功能障碍。

加州大学圣地亚哥医学院(University of California San Diego School of Medicine)的研究人员与来自巴西的同事们建立了一个由自闭症谱系障碍儿童(ASD)衍生的神经元与星形胶质细胞之间相互作用的模型,他们说,星形胶质细胞的先天炎症似乎在某种形式的疾病中会导致神经功能障碍。

这一发现发表在最新一期的《Biological Psychiatry》上,是首个证明星形胶质细胞(支持细胞)可能在ASD的某些亚型中起作用。但更重要的是,这项研究使用诱导多能干细胞,表明神经元损伤可能通过新的抗炎治疗逆转。

在这项研究中,科学家们从三名患有非综合征性自闭症(正在进行的“Tooth Fairy Project”)的儿童捐赠的乳牙中获取牙髓细胞,并重新编码这些细胞成为神经元或星形胶质细胞(一类在大脑中广泛存在的神经胶质细胞或支持细胞)。这些细胞成长为有机体,其本质上可以看作缩小的迷你大脑。

虽然存在遗传特异性,但这三个孩子都表现出典型的ASD行为,比如缺乏语言技能或社交互动。当研究人员在显微镜下观察这些发育的组织细胞时,他们发现神经元的突触更少,同时还有其他网络缺陷。此外,一些星形胶质细胞显示高水平的白细胞介素6(IL-6,一种促炎蛋白)。高水平的IL-6对神经元有毒性。

研究人员共同培养来自正常组的神经元以及来自ASD儿童的星形胶质细胞。该文的联合资深作者AlyssonR. Muotri博士说,健康的神经元的表现与ASD的神经元一样。他是加州大学圣地亚哥医学院儿科和细胞分子医学系的教授,同时是加州大学圣地亚哥分校干细胞项目的主任,也是桑福德再生医学联盟的成员。

但更重要的是,反过来也正确。当我们用正常的星形胶质细胞共同培养ASD神经元时,细胞缺陷还可以挽救。神经元会恢复正常功能和行为。

Muotri和他的同事们说,这些数据表明,在ASD的人群中可能存在一种内在的炎症反应。“如果我们能通过基因组测序来预测这个亚群,或许能发现使用抗炎药治疗自闭症的潜在可能性。”

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    2018-02-09 sunylz
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    2018-01-31 hzj0913

    一些星形胶质细胞显示高水平的白细胞介素6(IL-6.一种促炎蛋白).高水平的IL-6对神经元有毒性.

    0

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    2017-10-26 chunjianf

    学习了.谢谢分享!

    0

  5. 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createdName=hzj0913, createdTime=Wed Jan 31 23:52:46 CST 2018, time=2018-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767265, encodeId=878a1e6726563, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sat Apr 07 00:54:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256015, encodeId=3318256015a4, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Thu Oct 26 06:40:42 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318925, encodeId=ebe313189255f, content=<a href='/topic/show?id=421a5968510' target=_blank style='color:#2F92EE;'>#星形胶质细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59685, encryptionId=421a5968510, topicName=星形胶质细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60b4474, createdName=bbwuyu_003, createdTime=Sun Oct 22 13:54:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389187, encodeId=b197138918ee7, content=<a href='/topic/show?id=acf3840e459' target=_blank 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22 13:54:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254991, encodeId=6104254991bd, content=阅读.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Oct 22 06:40:55 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254807, encodeId=753425480e02, content=有这种事.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Oct 21 08:29:49 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254741, encodeId=6c48254e41cc, content=新发现.着临床研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Oct 21 06:28:39 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-22 xiongke014
  8. 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22 13:54:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254991, encodeId=6104254991bd, content=阅读.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Oct 22 06:40:55 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254807, encodeId=753425480e02, content=有这种事.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Oct 21 08:29:49 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254741, encodeId=6c48254e41cc, content=新发现.着临床研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Oct 21 06:28:39 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-22 刘煜

    阅读.谢谢分享

    0

  9. 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22 13:54:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254991, encodeId=6104254991bd, content=阅读.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Oct 22 06:40:55 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254807, encodeId=753425480e02, content=有这种事.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Oct 21 08:29:49 CST 2017, time=2017-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254741, encodeId=6c48254e41cc, content=新发现.着临床研究结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Oct 21 06:28:39 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 惠映实验室

    有这种事.学习了

    0

  10. 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    2017-10-21 yjs木玉

    新发现.着临床研究结果

    0

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