Clinica Chimica Acta:抗补体因子H自身抗体可能对狼疮性肾炎有保护作用

2020-05-30 MedSci原创 MedSci原创

这项研究旨在根据明确的队列研究抗CFH自身抗体在狼疮性肾炎中的作用。

这项研究旨在根据明确的队列研究抗CFH自身抗体在狼疮性肾炎中的作用。研究人员收集120例经活组织检查证实为活动性狼疮性肾炎的患者作为发现队列,60例作为验证队列,34例无肾红斑狼疮(NR-SLE)患者作为疾病对照,并纳入30例健康供体。采用ELISA检测抗CFH自身抗体和IgG亚类,western blot检测表位。采用亲和色谱柱纯化CFH自身抗体,体外采用C3b结合实验和辅助因子活性实验进一步研究CFH对生物功能的干扰。

狼疮性肾炎中抗CFH自身抗体的患病率显著高于健康对照组(8.3%(10/120)对0%(0/30),P = 0.017),发现之间没有显著差异验证组(8.3%(10/120)对11.7%(7/60),P = 0.268)或发现和NR-SLE组(8.3%(10/120)对11.8%(4 / 34),P = 0.231)。该亚类主要是IgG2(7/10),主要抗原决定簇位于CFH的中间(SCR 11–14中为8/10)和N端(SCR 1–4中为7/10)。患有抗CFH自身抗体的患者的急性肾损伤患病率显著较低(0%(0/10)比40.0%(4/10),P = 0.025),血清肌酐水平较低(0.76(0.40,1.06)与1.43(0.46,11.15),mg / dL,P = 0.023)和更高的血红蛋白水平(113.8±24.63 vs. 90.0±22.53,g / L,P = 0.037)比在进一步分层分析后呈阴性的患者更高。功能研究表明,从狼疮性肾炎患者体内纯化的抗CFH自身抗体可改善CFH与C3b​​之间的结合,并增强CFH的辅因子活性。

研究表明,在大约10%的多表位和IgG2亚类占优势的狼疮性肾炎患者中检测到抗CFH自身抗体。抗CFH自身抗体的患者表现为较轻的肾损害,纯化后的自身抗体在体外可增强CFH的C3b结合和CFI辅助因子活性,提示其在狼疮性肾炎中起保护作用。

原始出处:

Lin-Lin LiYing TanAnti-complement factor H autoantibodies may be protective in lupus nephritis

 

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    2020-11-16 windight
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    2020-06-01 villahu
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