脱发有救了!Nature子刊揭示:这种免疫细胞竟然是头发再生的关键

2022-07-03 Swagpp MedSci原创

自然·免疫学:调节性T细胞(regulatory T cell,Treg细胞)能够感受脱发部位糖皮质激素水平变化,释放TGF-β3,激活毛囊干细胞增殖,毛囊由休止期进入生长期,头皮焕发生机。

头发脱落,
是风的追求,
还是头皮的不挽留,
花儿谢了明年还是一样的开,
我的秀发一去,还回得来吗?
要想生发,就需要毛囊内的“种子”——毛囊干细胞能够源源不断生成新发。但是,光有毛囊干细胞还不够,因为在大部分时间里,毛囊干细胞都是处于一个休眠的状态,如果不能唤醒沉睡的毛囊干细胞,一样要面临“后继无发”的悲剧。
要能有一位管家能够及时唤醒毛囊干细胞,那是再好不过了。
诶,还别说,真有这么一种细胞在毛囊干细胞周围担任管家一职,近期来自美国Salk研究所的科学家就发现调节性T细胞(regulatory T cell,Treg细胞)能够感受脱发部位糖皮质激素水平变化,释放TGF-β3,激活毛囊干细胞增殖,毛囊由休止期进入生长期,头皮焕发生机。该研究发表于《自然·免疫学》。
图片
Treg细胞早期又被称为抑制性T细胞,是一类负调节机体免疫反应的T淋巴细胞,对维持自身耐受和限制免疫反应过度起着重要作用,但也参与肿瘤细胞的免疫逃逸和慢性感染。除此之外,Treg细胞同时还肩负着另一重功能,那就是维持组织稳定,促进组织修复和再生。
而糖皮质激素作为临床上使用最为广泛的抗炎和免疫抑制剂,长期使用的副作用除了有满月脸,水牛背之外,还有一点就是多毛症!
糖皮质激素与毛发的联系还不止于此,抓一只小鼠给它脱毛,脱毛区局部皮肤内糖皮质激素水平会短暂上升,同时毛囊干细胞周围的Treg细胞上的糖皮质激素受体的表达非常高,而这一切恰好就赶在了毛囊干细胞活化的时间点,要说它们仨没有联系,那反正研究人员是不太信的。
图片
注:脱毛后皮肤局部糖皮质激素水平在48小时内迅速升高,血液中的糖皮质激素水平则没有变化
为了研究糖皮质激素和Treg细胞在生发过程中起到怎样的作用,他们选择将小鼠Treg细胞上的糖皮质激素受体敲除(GR cKO),切断Treg细胞和糖皮质激素之间的直接联系,然后给小鼠背部脱毛。
在脱毛后第15天,正常小鼠背部毛发就已经“春风吹又生”,而GR cKO小鼠毛发只长了不到20%。
图片
注:脱毛后15天,两组小鼠毛发再生情况
组织学显示正常小鼠新生毛发明显要长于GR cKO小鼠,且已经突破真皮脂肪层野蛮生长了,而GR cKO小鼠的毛囊细胞还未破“土”而出。
图片
进一步分析正常小鼠和GR cKO小鼠毛囊干细胞的状态,脱毛后正常小鼠毛囊干细胞迅速从休眠状态激活,细胞增殖、分化基因表达上升,Ki67、EdU染色增加标志着毛囊干细胞开始分裂,毛囊由休止期进入到生发期。反观脱毛后的GR cKO小鼠,增殖的毛囊干细胞寥寥无几。
以上现象说明:敲除了Treg细胞上的糖皮质激素受体,将导致脱毛后毛囊干细胞不能正常增殖,毛发再生困难。
图片
为什么敲除Treg细胞上的糖皮质激素受体会对毛囊干细胞产生如此大的影响?
研究人员先是分析敲除糖皮质激素受体后,Treg细胞免疫调节功能是否受损。体内、体外实验结果均证明糖皮质激素受体敲除一点不影响Treg细胞发挥免疫抑制作用,“敲除Treg细胞糖皮质激素受体使得Treg细胞免疫功能障碍,毛囊干细胞周围环境免疫失衡,进一步引起毛囊干细胞一蹶不振”的猜想就此告吹。
接下来研究人员又猜测Treg细胞上的糖皮质激素受体可能对Treg细胞释放某种因子,激活毛囊干细胞至关重要。分析脱毛后正常小鼠、GR cKO小鼠Treg细胞、毛囊干细胞之间可能存在的信号通路,研究人员发现,脱毛后正常小鼠的Treg细胞TGF-β3表达量增加,促进毛囊干细胞内BMP信号通路由脱毛前抑制生发的pSmad1/5向激活生发的pSmad2/3转变,而在GR cKO小鼠脱毛前后Treg细胞和毛囊干细胞则没有发生类似的改变。
进一步的验证实验中,研究人员向正常小鼠脱毛区注射TGF-β3中和抗体,正常小鼠脱毛区的注射部位也变得像GR cKO小鼠一样寸草不生;而如果向GR cKO小鼠脱毛区注射TGF-β3,就能看到GR cKO小鼠脱毛区注射部位终于沙漠变绿洲,毛囊干细胞总算是醒了。
图片
总结一下,这篇研究讲的其实就是头发脱落后,脱发区局部糖皮质激素会增加,糖皮质激素和Treg细胞上的糖皮质激素受体结合,促进Treg细胞分泌TGF-β3,激活毛囊干细胞进入增殖状态,毛发再生。唤醒沉睡的毛囊干细胞,管家Treg细胞功不可没。
实际上,在临床中糖皮质激素早已被用来治疗斑秃,只不过大家都以为糖皮质激素发挥主要作用就是抑制免疫细胞功能,避免免疫细胞攻击毛囊,降低头皮炎症反应。这是科学家第一次发现糖皮质激素治疗脱发的过程中,还能与Treg细胞产生联系。
图片

参考资料:

Liu Z, Hu X, Liang Y, et al. Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche [published online ahead of print, 2022 Jun 23]. Nat Immunol. 2022;10.1038/s41590-022-01244-9. doi:10.1038/s41590-022-01244-9

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
    2023-02-13 liye789132251
  2. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
    2022-07-05 1801f26e0em

    用什么药治疗脱发呢?

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
    2022-07-04 qindq
  4. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
    2022-07-03 huaguang

    激活毛囊干细胞增值就能使毛囊进去生长期

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
    2022-07-03 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]
    2022-07-03 ms6000000960504356

    不错的文章

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1885860, encodeId=fae418858600e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 13 18:07:12 CST 2023, time=2023-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230613, encodeId=3a671230613b8, content=用什么药治疗脱发呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=480f2082257, createdName=1801f26e0em, createdTime=Tue Jul 05 07:36:00 CST 2022, time=2022-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468621, encodeId=5b26146862180, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Mon Jul 04 14:07:12 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230308, encodeId=fe09123030854, content=激活毛囊干细胞增值就能使毛囊进去生长期, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b6c1974111, createdName=huaguang, createdTime=Sun Jul 03 16:45:37 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230261, encodeId=b6a612302612f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 03 12:57:10 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230260, encodeId=9bbd123026046, content=<a href='/topic/show?id=8f275032126' target=_blank style='color:#2F92EE;'>#期刊论坛#</a><a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50321, encryptionId=8f275032126, topicName=期刊论坛), TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:32 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230259, encodeId=b96c123025936, content=不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0825417521, createdName=ms6000000960504356, createdTime=Sun Jul 03 12:47:23 CST 2022, time=2022-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230233, encodeId=da901230233f1, content=<a href='/topic/show?id=15098523e34' target=_blank style='color:#2F92EE;'>#脱发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85237, encryptionId=15098523e34, topicName=脱发)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Jul 03 09:09:55 CST 2022, time=2022-07-03, status=1, ipAttribution=)]

相关资讯

Nature:揭示大脑调节性T细胞促进神经系统恢复机制

除了维持免疫耐受外,FOXP3+调节性T细胞(regulatory T cell, Treg)在组织稳态和重塑中发挥着特殊功能。然而,大脑Treg细胞的特征和功能仍然是不清楚的,这是因为在正常条件下大脑中存在少量的Treg细胞。

Circulation:动脉粥样硬化中的保护性CD4 T调节细胞的致病性转换

在伴随动脉粥样硬化的炎症反应过程中,自身反应CD4+ T辅助细胞在动脉粥样硬化斑块中积累。载脂蛋白B100(apoB),低密度脂蛋白的核心蛋白,是一种自身抗原,可驱动产生致病性1型T-辅助 (TH1)

Genentech与Parvus结成了8亿美元的自身免疫性疾病药物研发联盟

罗氏公司的Genentech部门已与Parvus Therapeutics公司签署了一项许可协议,利用其Navacim平台开发炎症性肠病、自身免疫性肝病和乳糜泻的候选药物。

Circulation:抑制Notch-1可增强器官移植的耐受性!

移植是多种终末期器官疾病患者的最终选择。虽然在免疫抑制方面取得了进展,但由于药物毒性和免疫介导性损伤的阻碍,移植患者的长期预后仍不理想。因此,开发可同时提高移植物存活率和最小化常规免疫抑制的新疗法至关重要。Notch信号通路是一条高度保守的对T细胞分化和功能至关重要的通路,是调控T细胞介导的免疫的研究热点。研究人员对Notch-1在实体器官移植的小鼠和人受体的效应T细胞和调节T细胞(Tregs)中

Circulation:CXCR4阻滞通过增强Treg细胞活化促进梗死心肌修复

急性心肌梗死(MI)引发炎症反应,可驱动组织修复,诱发心室重构。MI后的炎症细胞转运由C-X-C模体趋化因子配体12 (CXCL12)及其受体C-X-C模体趋化因子4 (CXCR4)调控。CXCR4拮抗剂可激活炎症细胞,促进梗死修复,但其作用机制尚不明确。研究人员在MI再灌注的小鼠模型上研究CXCR4拮抗剂POL5551的治疗潜能和作用机制。研究人员通过淋巴细胞缺陷型Rag1敲除小鼠、DEREG小

Nat Commun:抗GARP:TGF-β1单抗能克服PD-1/PD-L1抑制剂耐药性

调节性T细胞(Treg)的免疫抑制作用对于外周免疫耐受的维持是不可或缺的,在癌症或慢性感染中该作用具有有害性。因此,在癌症患者中靶向Treg细胞及其功能的治疗策略的研究显得尤为重要。