J Am Geriatr Soc:长期服用双磷酸盐类防治骨质疏松性骨折的弊端!

2017-06-04 枫丹白露 来宝网

骨质疏松症是一种导致骨骼变薄,骨密度降低和骨骼愈来愈脆弱的疾病。这使人骨骼骨折的风险更高。随着年龄的增长,疾病的风险也会增加。事实上,50岁以上的妇女容易因骨质疏松而遭受骨折。

骨质疏松症是一种导致骨骼变薄,骨密度降低和骨骼愈来愈脆弱的疾病。这使人骨骼骨折的风险更高。随着年龄的增长,疾病的风险也会增加。事实上,50岁以上的妇女容易因骨质疏松而遭受骨折。

到2020年,估计有6100万美国成年人的骨矿物质密度较低。称为“双膦酸盐”的药物有时用于治疗骨质疏松症。这些药物增加骨矿物质密度,这加强了骨骼,并被认为使它们不太可能破裂。研究表明,当骨质疏松的妇女服用这些药物1至4年时,骨折的风险降低。然而,关于长时间服用双膦酸盐是否具有相同的效果,知之甚少。

最近,一组研究人员研究了服用二膦酸盐治疗10-13年的老年妇女骨质疏松症性骨折的发生率是否比具有相似风险但仅短暂服用这些药物的老年妇女更低。他们的研究发表在美国老年病学会杂志上。研究小组研究了妇女健康计划研究的数据,该研究是1993年开始的一项大型研究,旨在开发减少绝经后妇女心脏病,癌症和骨折的方法。研究人员研究了5120名妇女的资料。这些妇女是骨质疏松高风险的双膦酸盐使用者。

研究中95%以上的参与者超过70岁,平均年龄约为80岁. 研究开始时这些女性服用二膦酸盐的时间长度如下:

13%为2年

34%为3 - 5年

20%为6-9年

33%为10 - 13年

研究人员在研究中随访了这些妇女近4年。他们发现,使用二膦酸盐治疗10-13年的女性,与服用2年的妇女相比,骨折率更高。服用双膦酸盐3-9年与较高的骨折风险无关。

“与短期使用者相比,我们的研究和其他几项研究发现,非常长期的双膦酸盐使用者的骨折风险较高,但是在随机临床试验中尚未研究二膦酸盐使用的理想长度, Rebecca L. Drieling,MPH说:长期的双膦酸盐使用者应该看看他们的医疗保健提供者决定在个别情况下继续使用双膦酸盐治疗的时间。

原始出处:

Rebecca L. Drieling, Andrea Z. LaCroix, et al. Long-Term Oral Bisphosphonate Therapy and Fractures in Older Women: The Women's Health Initiative. Journal of the American Geriatrics SocietyFirst published: 29 May 2017 DOI: 10.1111/jgs.14911

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1801466, encodeId=74c71801466af, content=<a href='/topic/show?id=7f37e38609a' target=_blank style='color:#2F92EE;'>#磷酸盐类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73860, encryptionId=7f37e38609a, topicName=磷酸盐类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Thu Aug 17 02:21:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736099, encodeId=81211e360990f, content=<a href='/topic/show?id=79863e54910' target=_blank style='color:#2F92EE;'>#双磷酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37549, encryptionId=79863e54910, topicName=双磷酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, 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time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206541, encodeId=1b142065411f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jun 04 20:25:10 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206492, encodeId=9a03206492ba, content=未来的发展前景广阔, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 04 19:13:02 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206478, encodeId=e3c52064e872, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 04 18:54:30 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
    2017-06-06 Eleven17
  8. 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time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206541, encodeId=1b142065411f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jun 04 20:25:10 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206492, encodeId=9a03206492ba, content=未来的发展前景广阔, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 04 19:13:02 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206478, encodeId=e3c52064e872, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 04 18:54:30 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
    2017-06-04 changjiu

    学习了,谢谢分享

    0

  9. 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time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206541, encodeId=1b142065411f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jun 04 20:25:10 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206492, encodeId=9a03206492ba, content=未来的发展前景广阔, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jun 04 19:13:02 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206478, encodeId=e3c52064e872, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jun 04 18:54:30 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
    2017-06-04 虈亣靌

    未来的发展前景广阔

    0

  10. 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    2017-06-04 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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