Arch Oral Biol:龋齿儿童唾液中氧化应激生物标志物和唾液参数会发生改变

2022-09-09 MedSci原创 MedSci原创

研究表明,在患有龋齿的儿童中,唾液抗氧化剂对氧化应激的反应有其独特的表现,但是现有的研究结果并不一致。

研究表明,在患有龋齿的儿童中,唾液抗氧化剂对氧化应激的反应有其独特的表现,但是现有的研究结果并不一致。近日,发表于Arch Oral Biol的一项系统综述和荟萃分析旨在评估与氧化应激有关的唾液生物标志物水平,以及与患有或不患有龋齿的儿童的唾液参数之间的关系。

研究纳入12岁以下儿童,比较唾液中氧化应激的生物标志物,如丙二醛(MDA)、超氧化物歧化酶(SOD)、尿酸和总抗氧化能力(TAC),考虑有龋齿病变的儿童和无龋齿儿童。此外,还评估了唾液参数,如唾液流量、pH值、缓冲能力、钙和总蛋白水平。在8个数据库中进行了系统的文献回顾。使用反方差作为统计方法和随机效应作为分析模型,测量标准化平均差异(SMD),对应95%的置信区间(CI)。

 

结果显示,与无龋齿儿童(对照组)相比,受龋齿影响的儿童的TAC水平较高,与年龄(SMD 2.66,CI 1.33,3.98)或性别(SMD 0.98,CI 0.56,1.39)无关。校正正常蛋白后,龋齿组的MDA水平低于对照组(SMD -16.51,CI -29.02,-4.00),但是龋齿组的SOD水平更高(SMD 5.09,CI 0.01.10.18)。患有龋齿的儿童唾液中的总蛋白浓度高于对照组,与年龄(SMD 0.98, CI 0.27, 1.69)或性别(SMD 0.77, CI 0.45, 1.10)无关。评估的唾液参数在受龋齿影响的儿童中水平较低(P < 0.05)。

综上所述,该研究结果表明,患有龋齿的儿童唾液中的氧化应激生物标志物和唾液参数的水平有所改变。抗氧化系统生物标志物(TAC和SOD)和总蛋白浓度在受该疾病影响的儿童中显示为较高。另一方面,唾液氧化损伤生物标志物(MDA)和唾液流速、pH值、缓冲能力和钙等参数在有龋齿病变的儿童中显示出降低的数值。因此,可以认为,龋病对氧化应激生物标志物的水平有影响。

 

原始出处:

 

Jordana Resende Martins, et al., Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis. Arch Oral Biol. 2022 Jul;139:105432. doi: 10.1016/j.archoralbio.2022.105432.  

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    2023-03-21 sunylz
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    2023-01-04 小几洁
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