美国癌症研究协会:含糖饮料增加乳腺癌患者死亡风险近9成!

2021-03-12 MedSci原创 MedSci原创

对于这一“甜蜜的”负担,不管是对于健康人还是患者,应当控制含糖饮料及其他含有添加糖的食物摄入。

2016年,世界卫生组织(WHO)呼吁各界重视税收等政策运用,以提高含糖饮料售卖,从而帮助消费者改变饮食选择。而立意初衷是因为,大量研究证实,过量的添加糖,特别是含糖饮料的添加糖,是血管疾病和2型糖尿病等心血管代谢疾病的主要危险因素。

JAMA子刊曾报道,那些饮用含糖量最高的饮料(包括100%纯果汁)的人在研究期间死亡率要高于那些饮用含糖量最低的人。此外,每多摄入12盎司/日的含糖饮料,全因死亡风险会增加11%;而每多摄入12盎司/日的果汁,全因死亡风险就会增加24%。

含糖饮料(SSB)是指添加糖或甜味剂的饮料,包括苏打水、运动饮料和水果味饮料。但是,SSB乳腺癌患者死亡率的影响尚不清楚。为此,来自纽约州立大学布法罗分校的研究人员对SSB对乳腺癌患者死亡风险的影响进行了全面分析,结果发表在美国癌症研究协会(AACR)旗下期刊《癌症流行病学、生物指标和预防》(Cancer Epidemiology, Biomarkers & Prevention)杂志上。

研究人员评估了“纽约西部暴露和乳腺癌(WEB)”研究中,SSB与原发性、侵袭性乳腺癌女性的全因和乳腺癌死亡率之间的关系。在进行了中位随访18.7年后通过国家死亡指数(NDI)确定参与者的生命状态,通过食物频率问卷(FFQ)确定加糖苏打水的消费频率。

在927例乳腺癌患者中,386人(54.7%)在随访结束时死亡。与从不/很少喝SSB的人相比,每周≥5次引用SSB增加患者62%的全因死亡率和85%的乳腺癌特异性死亡率。进一步分析显示,ER阳性、BMI高于中位数、绝经前女性患者全因死亡率同样增加。

研究人员分析,SSB含有大量的蔗糖和果糖,与其它非含糖饮料相比,含糖饮料的血糖负荷最高。而这些较高浓度的葡萄糖和胰岛素,可能导致乳腺癌患者死亡风险增加。相比之下,茶或咖啡,可能是癌症患者更健康的饮料选择,因为这些饮料含有抗氧化剂和维生素,具有更高的营养价值。

不过,研究人员也指出,该研究的局限性在于是观察性报道,只能提示饮用SSB与乳腺癌患者死亡风险升高之间存在关联,但并不能说明有因果关系,也就是说不能确定饮用含糖饮料,一定是导致乳腺癌患者死亡风险升高的原因。

但是,鉴于已有大量研究证实了SSB对健康的百害而无一利,那么无疑这个结果又给含糖饮料增加了新的“罪证”。为此,对于这一“甜蜜的”负担,不管是对于健康人还是患者,应当控制含糖饮料及其他含有添加糖的食物摄入。

 

参考文献:

Koyratty N,et al. Sugar-Sweetened Soda Consumption and Total and Breast Cancer Mortality: The Western New York Exposures and Breast Cancer (WEB) Study. Cancer Epidemiol Biomarkers Prev. 2021 Mar 2:cebp.1242.2020. doi: 10.1158/1055-9965.EPI-20-1242.

 

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    2021-03-14 ms5000000892437705

    好👍

    0

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