Sci Rep:中年男性中与下尿路症状相关因素研究

2019-02-15 AlexYang MedSci原创

最近,有研究人员前瞻性的调查了血清睾酮水平与LUTS在年龄不小于40岁且接受体检的中年男性中的相关性。研究包括了1752名男性,平均年龄为55.6±9.7岁。所有的研究对象通过2个截断值(3.0和4.11ng/mL)分为低、中和高睾酮水平。研究人员发现,睾酮水平与代谢症状和身体脂肪组成显著相关。与那些低睾酮水平的受试者相比,高和中等睾酮水平的受试者具有显著更高的IPSS(5.84±5.55 vs

最近,有研究人员前瞻性的调查了血清睾酮水平与LUTS在年龄不小于40岁且接受体检的中年男性中的相关性。

研究包括了1752名男性,平均年龄为55.6±9.7岁。所有的研究对象通过2个截断值(3.0和4.11ng/mL)分为低、中和高睾酮水平。研究人员发现,睾酮水平与代谢症状和身体脂肪组成显著相关。与那些低睾酮水平的受试者相比,高和中等睾酮水平的受试者具有显著更高的IPSS(5.84±5.55 vs 6.71±5.68和6.34±5.66, p=0.032)和储存评分(2.76±2.29 vs 3.20±2.49和2.90±2.49; p=0.009)以及更加中度/严重的LUTS(IPSS≧8) (26.5% vs 35.7%和29.9%; p=0.002)。多变量分析表明高与低睾酮水平(OR, 1.76; 95% CI, 1.26-2.45)和前列腺体积不大于25和小于25Ml(OR, 1.38; 95% CI, 1.04-1.82)均与中度/重度LUTS的存在显著相关。皮尔逊相关分析表明了在整个研究群体和中度/重度LUTS亚群中,睾酮水平与IPSS具有显著的正相关关系(皮尔逊相关系数和显著性分别为:0.066,p<0.01和0.038,p<0.05)。

最后,研究人员指出,高睾酮水平和前列腺体积在他们的靶向群体中对LUTS具有不良的影响。

原始出处:

Teng-Kai Yang, Chi-Chih Chang, Hong-Chiang Chang et al. Factors Associated with Bothersome Lower Urinary Tract Symptoms in Middle-Aged Men Receiving Health Checkup. Sci Rep. 29 Jan 2019.

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