J Am Heart Assoc:芬兰学者在脑血栓中发现口腔细菌DNA

2019-05-28 xujing 中国循环杂志

芬兰坦佩雷大学的研究人员在美国心脏协会杂志上发表研究称,他们首次在急性缺血性卒中患者的脑血栓中发现了在口腔中存在的链球菌属的DNA。这进一步表明口腔细菌可能在脑血管疾病中起作用。

芬兰坦佩雷大学的研究人员在美国心脏协会杂志上发表研究称,他们首次在急性缺血性卒中患者的脑血栓中发现了在口腔中存在的链球菌属的DNA。这进一步表明口腔细菌可能在脑血管疾病中起作用。

研究人员对75例急性缺血性卒中患者(69%男性,平均年龄67岁)进行血栓抽吸和动脉血检测。

研究者采用特异性引物和探针定量聚合酶链反应法,测定了样品中存在的链球菌种类,主要为丝裂霉素类,属于病毒科链球菌,以及牙龈卟啉单胞菌和聚集放线菌。

结果显示,79%的血栓抽吸液中发现了来自口腔的以丝裂霉素为主的链球菌属的DNA。

与同一患者的正常血样相比,在脑血栓中的链球菌属DNA的中位相对含量高出5.10倍。

在口腔中,链球菌是无害的,但是当进入血液循环时,它们可能会引起心脏瓣膜的感染。链球菌可直接与各种血小板受体结合,形成血栓。

研究者强调,牙齿的细菌感染引起的反复短暂菌血症,可能会将病原体困在动脉粥样硬化斑块中,并促进斑块破裂;因此,在急性缺血性卒中的一级预防中,应强调常规牙科护理。

原始出处:
Patrakka O1, Pienim?ki JP2, Tuomisto S1, et al.Oral Bacterial Signatures in Cerebral Thrombi of Patients With Acute Ischemic Stroke Treated With Thrombectomy.J Am Heart Assoc. 2019 Jun 4;8(11):e012330. doi: 10.1161/JAHA.119.012330.

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    2019-05-30 zhaojie88
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    2019-05-30 slcumt