Science：手术并发症频发，罪魁祸首竟是免疫细胞！

2021-03-08 MedSci原创 MedSci原创

腹膜巨噬细胞既可以促进伤口愈合，又能引发严重的手术副作用。

粘连通常是手术后形成的内部疤痕组织，在组织和器官之间形成的纤维带连接了通常不连接的组织。粘连形是受伤后人体愈合过程的自然部分，其形成方式与疤痕形成类似。手术后通常会在两个受伤的表面彼此靠近时发生粘连形成。这通常会引起炎症，并导致纤维蛋白沉积在受损组织上。然后，血纤蛋白将两个相邻的结构连接在一起，从而发生组织损伤。尽管某些粘连不会引起问题，但一些例外显示部分粘连可能会阻止肌肉和其他组织器官的自由移动，有时会导致器官扭曲或从正常位置拉出，继而引发严重的术后并发症。腹腔粘连（或腹腔内粘连）最常见是由腹部外科手术引起的。粘连在手术后数小时内开始形成，并可能导致内部器官附着在手术部位或腹腔中的其他器官上。内脏器官与粘附相关的扭曲和牵拉可能会导致腹痛或肠梗阻。根据美国国家医院提供的调查统计数据，在美国，每年约有2000人因粘连而死于小肠梗阻，成千上万的患者因术后粘连而需要接受去粘连后续手术。近日，加拿大卡尔加里大学的一个研究小组在国际顶级期刊Science上发表题为Surgical adhesions: A sticky macrophage problem的研究论文。研究结果表明身体

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2021-06-13 丁鹏鹏

#并发#

42 0
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2021-12-14 1249894fm73暂无昵称

#手术并发症#

25 0
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2021-03-15 ms6000001617230459

受教了

49 0
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2021-03-09 ms9000000683869843

免疫细胞不想背锅

70 0
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2021-03-09 jichang

#SCIE#

39 0
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2021-03-08 科研科研科研

手术并发症频发

66 0
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2021-03-08 白三夕

可以

64 0
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2021-03-08 ms1000002074735373

👍🏻

74 0

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