Stroke:非酒精性脂肪肝严重程度与缺血性卒中风险的关系

2020-12-08 MedSci原创 MedSci原创

NAFLD的严重程度与未来较高的IS事件风险相关。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在前瞻性地评估非酒精性脂肪肝疾病(NAFLD)及其严重程度是否可预测以社区为基础的队列缺血性卒中(IS)事件的发生情况。

在排除酗酒和其他肝脏疾病后,研究人员招募了无卒中、癌症或心肌梗塞病史的参与者。通过超声检查评估NAFLD。NAFLD的参与者进一步分为轻度、中度和重度。结局为首次出现IS。次要结局包括心肌梗塞和合并的血管事件。研究人员调整了年龄、性别、身体活动、体重指数、吸烟者、高血压病史、糖尿病、高胆固醇血症、血脂水平、降脂药物、高密度脂蛋白(HDL)、甘油三酯、高敏C反应蛋白(hsCRP)和空腹血糖等因素,并使用Cox比例风险模型根据NAFLD有无和严重程度来估计IS事件的风险比和95%CI。

在平均10.34年的随访期间,研究人员从79905名参与者中记录到了3490例卒中事件。在24874名(31.18%)参与者中发现了NAFLD。相对于基线时无NAFLD的参与者,经混杂变量调整后,NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15(95%CI为1.05–1.25)、1.19(95%CI为1.06-1.34)和1.21(95%CI为1.08-1.50)。

由此可见,NAFLD的严重程度与未来较高的IS事件风险相关。

原始出处:

Jie Xu.et al.Severity of Nonalcoholic Fatty Liver Disease and Risk of Future Ischemic Stroke Events.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.030433

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06:50:49 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906318, encodeId=b65f90631870, content=NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15、1.19和1.21。要重视轻度脂肪肝!<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a> <a href='/topic/show?id=6be91040e238' target=_blank style='color:#2F92EE;'>#轻度脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=104072, encryptionId=6be91040e238, topicName=轻度脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 09 10:51:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026722, 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  5. 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  6. 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  7. 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topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sun Mar 07 16:50:49 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676616, encodeId=a25b16e6616dc, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Thu Apr 01 22:50:49 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673642, 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06:50:49 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906318, encodeId=b65f90631870, content=NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15、1.19和1.21。要重视轻度脂肪肝!<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a> <a href='/topic/show?id=6be91040e238' target=_blank style='color:#2F92EE;'>#轻度脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=104072, encryptionId=6be91040e238, topicName=轻度脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 09 10:51:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026722, 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  8. 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06:50:49 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906318, encodeId=b65f90631870, content=NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15、1.19和1.21。要重视轻度脂肪肝!<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a> <a href='/topic/show?id=6be91040e238' target=_blank style='color:#2F92EE;'>#轻度脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=104072, encryptionId=6be91040e238, topicName=轻度脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 09 10:51:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026722, encodeId=ad701026e2219, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Dec 08 18:50:49 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045994, encodeId=3e5a104599468, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 08 18:50:49 CST 2020, time=2020-12-08, status=1, ipAttribution=)]
    2020-12-09 Jessica

    NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15、1.19和1.21。要重视轻度脂肪肝!#卒中# #轻度脂肪肝#

    0

  9. 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createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Sep 05 09:50:49 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893340, encodeId=96a2189334038, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Feb 17 20:50:49 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820431, encodeId=1a4c182043172, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Sun Mar 07 16:50:49 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676616, encodeId=a25b16e6616dc, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Thu Apr 01 22:50:49 CST 2021, time=2021-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673642, encodeId=7dd516e3642cc, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Fri Apr 02 06:50:49 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281353, encodeId=4961128135324, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Dec 10 06:50:49 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906318, encodeId=b65f90631870, content=NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15、1.19和1.21。要重视轻度脂肪肝!<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a> <a href='/topic/show?id=6be91040e238' target=_blank style='color:#2F92EE;'>#轻度脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=104072, encryptionId=6be91040e238, topicName=轻度脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 09 10:51:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026722, encodeId=ad701026e2219, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Dec 08 18:50:49 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045994, encodeId=3e5a104599468, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 08 18:50:49 CST 2020, time=2020-12-08, status=1, ipAttribution=)]
    2020-12-08 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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encodeId=7dd516e3642cc, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Fri Apr 02 06:50:49 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281353, encodeId=4961128135324, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Dec 10 06:50:49 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906318, encodeId=b65f90631870, content=NAFLD患者发生IS的风险升高16%(95%CI为1.07-1.26)。轻度、中度和重度NAFLD患者的风险比分别为1.15、1.19和1.21。要重视轻度脂肪肝!<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a> <a href='/topic/show?id=6be91040e238' target=_blank style='color:#2F92EE;'>#轻度脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=104072, encryptionId=6be91040e238, topicName=轻度脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Dec 09 10:51:02 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026722, encodeId=ad701026e2219, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Dec 08 18:50:49 CST 2020, time=2020-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045994, encodeId=3e5a104599468, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 08 18:50:49 CST 2020, time=2020-12-08, status=1, ipAttribution=)]
    2020-12-08 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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