Clin Cancer Res：基于智能分析的基因特征可预测采用奥沙利铂一线化疗的晚期结直肠癌预后

2021-01-19 MedSci原创 MedSci原创

FOLFOX、FOLFIRI或FOLFOXIRI化疗联合贝伐单抗（BV）被认为是转移性结直肠癌(mCRC)患者的标准一线治疗选择。本研究旨在开发和验证可预测以奥沙利铂为基础的化疗联合BV对mCRC患者

FOLFOX、FOLFIRI或FOLFOXIRI化疗联合贝伐单抗（BV）被认为是转移性结直肠癌(mCRC)患者的标准一线治疗选择。本研究旨在开发和验证可预测以奥沙利铂为基础的化疗联合BV对mCRC患者的疗效的分子特征。

应用一种机器学习方法，并在来自真实世界证据(RWE)数据集的临床和二代测序数据以及来自前瞻性的TRIBE2研究的样本上进行测试，以识别分子特征FOLFOXai。算法训练将下一次治疗时间(TTNT)纳入考虑。验证研究采用TTNT、无进展生存期（PFS）和总生存期(OS)作为主要终点。

RWE数据集FOLFOX一线治疗患者预后

在训练队列(n=105)中，67个基因特征被交叉验证，表明FOLFOXai有能力区分FOLFOX治疗后受益增加（IB）或受益减少（DB）的mCRC患者。

RWE数据集FOLFIRI一线治疗患者预后

在412位采用FOLFOX/BV作为一线治疗的患者的独立RWE数据集中，上述基因特征对TTNT和OS具有预测作用，而在55位接受FOLFIRI作为一线治疗的患者的RWE数据中，该基因特征对生存期有相反的预测作用。

TRIBE2试验FOLFOX一线治疗患者预后

TRIBE2试验FOLFIRI一线治疗患者预后

对TRIBE2样本的盲法分析证实，FOLFOXai对含奥沙利铂的两组患者的OS均有预测作用(FOLFOX HR 0.629；p=0.04；FOLFOXIRI HR 0.483；p=0.02)。FOLFOXai还可预测奥沙利铂方案对晚期食管癌/胃-食管交界癌(EC/GEJC)以及胰腺导管腺癌 (PDAC)的治疗益处。

综上，FOLFOXai的应用可能促使预计从含奥沙利铂方案获益较少的患者及时选择可能有益的替代方案，从而改善mCRC和其他癌症患者的整体治疗预后。

原始出处：

Abraham Jim P,Magee Daniel,Cremolini Chiara et al. Clinical Validation of a Machine-learning-derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer. Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-20-3286.

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2021-07-04 okhuali

#一线化疗#

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2021-02-11 ms3153534357578991

#铂#

24 0
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2021-10-10 lishiwen

#能分析#

38 0
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createdName=ms3153534357578991, createdTime=Thu Feb 11 12:10:52 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809976, encodeId=966e18099e6fe, content=<a href='/topic/show?id=2b9d8426121' target=_blank style='color:#2F92EE;'>#能分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84261, encryptionId=2b9d8426121, topicName=能分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sun Oct 10 16:10:52 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992469, encodeId=35ef1992469d8, content=<a href='/topic/show?id=f51241e935c' target=_blank style='color:#2F92EE;'>#基因特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41793, 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objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Jan 21 09:10:52 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918248, encodeId=6de391824839, content=人工智能很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210209/c24ce6bb97bb4de0968e69be1f6d3ca4/93f7c058bb894fc39a47081bc5283bc1.jpg, createdBy=e3945412064, createdName=Wlgank, createdTime=Wed Jan 20 02:35:52 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918181, encodeId=dfc3918181e7, content=好文章, 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objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Jan 19 20:23:03 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
2021-10-08 1249859em38(暂无昵称)

#基因特征#

29 0
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createdName=ms3153534357578991, createdTime=Thu Feb 11 12:10:52 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809976, encodeId=966e18099e6fe, content=<a href='/topic/show?id=2b9d8426121' target=_blank style='color:#2F92EE;'>#能分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84261, encryptionId=2b9d8426121, topicName=能分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Sun Oct 10 16:10:52 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992469, encodeId=35ef1992469d8, content=<a href='/topic/show?id=f51241e935c' target=_blank style='color:#2F92EE;'>#基因特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41793, 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objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Jan 21 09:10:52 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918248, encodeId=6de391824839, content=人工智能很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210209/c24ce6bb97bb4de0968e69be1f6d3ca4/93f7c058bb894fc39a47081bc5283bc1.jpg, createdBy=e3945412064, createdName=Wlgank, createdTime=Wed Jan 20 02:35:52 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918181, encodeId=dfc3918181e7, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=027a2414373, createdName=1238220bm81暂无昵称, createdTime=Tue Jan 19 20:42:54 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918177, encodeId=717e9181e7ae, content=基于智能分析的基因特征可预测采用奥沙利铂一线化疗的晚期结直肠癌预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 19 20:28:48 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918174, encodeId=b4549181e4e7, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Jan 19 20:23:03 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
2021-09-18 huagfeg

#晚期结直肠癌#

46 0
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objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Jan 21 09:10:52 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918248, encodeId=6de391824839, content=人工智能很火啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210209/c24ce6bb97bb4de0968e69be1f6d3ca4/93f7c058bb894fc39a47081bc5283bc1.jpg, createdBy=e3945412064, createdName=Wlgank, createdTime=Wed Jan 20 02:35:52 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918181, encodeId=dfc3918181e7, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=027a2414373, createdName=1238220bm81暂无昵称, createdTime=Tue Jan 19 20:42:54 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918177, encodeId=717e9181e7ae, content=基于智能分析的基因特征可预测采用奥沙利铂一线化疗的晚期结直肠癌预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 19 20:28:48 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918174, encodeId=b4549181e4e7, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Jan 19 20:23:03 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
2021-01-21 crystal0564

#结直肠#

20 0
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beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=027a2414373, createdName=1238220bm81暂无昵称, createdTime=Tue Jan 19 20:42:54 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918177, encodeId=717e9181e7ae, content=基于智能分析的基因特征可预测采用奥沙利铂一线化疗的晚期结直肠癌预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 19 20:28:48 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918174, encodeId=b4549181e4e7, content=学习了，涨知识了！, beContent=null, 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2021-01-20 Wlgank

人工智能很火啊

84 0
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beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=027a2414373, createdName=1238220bm81暂无昵称, createdTime=Tue Jan 19 20:42:54 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918177, encodeId=717e9181e7ae, content=基于智能分析的基因特征可预测采用奥沙利铂一线化疗的晚期结直肠癌预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 19 20:28:48 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918174, encodeId=b4549181e4e7, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Jan 19 20:23:03 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
2021-01-19 1238220bm81暂无昵称

好文章

62 0
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2021-01-19 言西早

基于智能分析的基因特征可预测采用奥沙利铂一线化疗的晚期结直肠癌预后。

75 0
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objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Jan 19 20:23:03 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
2021-01-19 ms2000001051330459

学习了，涨知识了！

61 0

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