Biol Psychiatry:青少年期吸烟导致注意力缺陷障碍

2015-10-21 candy 译 MedSci原创

背景:吸烟和注意缺陷多动障碍(ADHD)是高度并存的。一个解释是,多动症的患者使用香烟作为“自我药物”,以减轻他们的注意力缺陷的问题。然而,动物研究报告说,在青春期的尼古丁暴露影响大脑发育和对负面影响的关注。这是第一次人类的研究,探索在青春期吸烟对注意力缺陷障碍的影响。方法:吸烟与注意力问题的纵向数据是从注册的荷兰双胞胎中获得,共计1987例成人和648例青少年期的同卵双胞胎。双胞胎根据是否吸烟被

背景:吸烟和注意缺陷多动障碍(ADHD)是高度并存的。一个解释是,多动症的患者使用香烟作为“自我药物”,以减轻他们的注意力缺陷的问题。然而,动物研究报告说,在青春期的尼古丁暴露影响大脑发育和对负面影响的关注。这是第一次人类的研究,探索在青春期吸烟对注意力缺陷障碍的影响。

方法:吸烟与注意力问题的纵向数据是从注册的荷兰双胞胎中获得,共计1987例成人和648例青少年期的同卵双胞胎。双胞胎根据是否吸烟被归类为一致和不一致,并比较其注意力问题。对于成人不一致双胞胎,在吸烟和不吸烟的双胞胎之间的注意力问题上的差异,应注意第一横截面的评估。在纵向分析中,到成年期均不吸烟的双胞胎与不一致的双胞胎。在亚组的纵向数据中,从童年和青春期后,吸烟的一致性和随后的变化对注意力问题的影响进行了探讨。

结果:从青春期到成年都保持吸烟的成年双胞胎较从来没有吸烟的另一位孪生双胞胎有更显著的注意力问题。纵向分析表明,在从青春期到成年均吸烟的双胞胎,较从来没有吸烟的双胞胎有更严重的注意力问题(p < .05)。在儿童和青少年时期吸烟的双胞胎比从来没有吸烟的双胞胎有更多的注意力问题,而在两个双胞胎均开始吸烟的前后,他们的注意力分数是相似的(组间无显著统计学差异)。

结论:从这一基因信息的研究结果表明,青春期吸烟所导致的注意力方面的缺陷,将会持续到成年。

原始出处:


Treur, J. L,et al.Smoking During Adolescence as a Risk Factor for Attention Problems.Biol Psychiatry .Nov 1,2015.78(9): 656-663.

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    2015-11-27 sunylz
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    2015-10-27 三三五五

    吸烟可以改变很多东西

    0

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    2015-10-21 pine007

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