安徽省立医院CRT应用经验:左心室限制性充盈冠心病患者疗效差

2018-01-04 许菁 中国循环杂志

安徽医科大学附属省立医院严激等研究发现,左心室舒张充盈模式影响心室再同步化(CRT)疗效,非限制性充盈模式的缺血性心肌病患者CRT 获益显著,限制性充盈模式的患者,CRT 反应率低、疗效差、预后不良。


安徽医科大学附属省立医院严激等研究发现,左心室舒张充盈模式影响心室再同步化(CRT)疗效,非限制性充盈模式的缺血性心肌病患者CRT 获益显著,限制性充盈模式的患者,CRT 反应率低、疗效差、预后不良。
 
本组接受CRT 的61例缺血性心肌病患者,非限制性充盈36例,其CRT 反应率为67%(24/36),限制性充盈25例,其CRT 反应率为28%(7/25)。
 
非限制性充盈组的患者术后3个月即出现心衰症状的改善,左心室射血分数提高,心腔容积缩小;至术后6个月,心衰症状及心室收缩功能继续改善的同时,心肌的逆重构反应更加显著。
 
限制性充盈患者仅出现术后的NYHA 心功能分级改善,术后反应心肌收缩功能的左心室射血分数及反应心肌逆重构的心室容积均无改善。
 
进一步分析显示,除了术前QRS 波时限, 肺动脉收缩压,舒张充盈模式也是CRT 有反应的独立影响因素。
 
随访12个月,限制性充盈患者的累积终点事件发生率76%,高于非限制性充盈组的44%。
 
研究者表示,术前不同舒张充盈模式的患者间CRT 疗效差异显著,因此术前常规评估舒张充盈模式,对CRT患者的筛选具有临床实践意义。

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