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J Hypertens：2型糖尿病合并高血压患者蛋白尿和肾功能的变化!

2018-04-21 xing.T MedSci原创

2型糖尿病高血压蛋白尿肾功能
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由此可见，在高血压合并T2D患者中，蛋白尿的变化与肾脏风险的变化相关。蛋白尿状态可指导优化治疗策略。

近日，高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章，研究人员旨在评估接受降压治疗的2型糖尿病（T2D）患者蛋白尿改变对肾功能减退的预测作用。

研究人员回顾性地分析了意大利100个糖尿病治疗中心内12611例高血压合并T2D患者的临床资料，这些患者基线时肾小球滤过率（eGFR）正常，并对4年期间的定期随访进行回顾性分析。研究人员评估了1年基线期间白蛋白尿状态的变化与随后4年随访中血压（BP）和eGFR降低之间的相关性。

受试者基线时平均年龄为65±9岁，糖尿病病程为11±8年，eGFR为85±13mL/min，BP为142±17/81±9mmHg。相比于正常的患者，持续性蛋白尿患者4年eGFR降低的风险最高，eGFR降低超过30%或发病为3期慢性肾脏病（eGFR＜60mL/min）(比值比为2，95%可信区间为1.71-2.34，P＜0.001)。女性、年龄、病程、BMI、低基线eGFR、血脂谱、抗高血压药物数量和蛋白尿状态的变化与整个研究人群的肾脏风险相关。此外，较低的血压值和肾素-血管紧张素-醛固酮系统抑制剂的使用仅在没有蛋白尿的患者亚群中与肾脏终点的发生有关。

由此可见，在高血压合并T2D患者中，蛋白尿的变化与肾脏风险的变化相关。蛋白尿状态可指导优化治疗策略。

原始出处：

Viazzi, Francesca,et al. Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Changes_in_albuminuria_and_renal_outcome_in.97480.aspx

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    2018-05-20 feather89

    #PE#

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    2018-12-26 yese

    #肾功能#

    0

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    2019-01-25 12498ebem19暂无昵称

    #TENS#

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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/27/6f2d63c799d68129300901eb0e962dd4.jpg, createdBy=ddf12178538, createdName=小贝熊, createdTime=Sun Apr 22 00:17:45 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-05-16 12031073m18暂无昵称

    学习

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Mon Apr 23 08:03:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308406, encodeId=88cd30840610, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Apr 23 06:53:11 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308286, encodeId=5df2308286a9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/27/6f2d63c799d68129300901eb0e962dd4.jpg, createdBy=ddf12178538, createdName=小贝熊, createdTime=Sun Apr 22 00:17:45 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-25 海之蓝

    学习

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Mon Apr 23 08:03:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308406, encodeId=88cd30840610, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Apr 23 06:53:11 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308286, encodeId=5df2308286a9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Apr 22 19:33:08 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308192, encodeId=d2c1308192e0, content=在高血压合并T2D患者中.蛋白尿的变化与肾脏风险的变化相关., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ad01994393, createdName=溜溜梅不酸, createdTime=Sun Apr 22 09:55:16 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308035, encodeId=fa073080357e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/27/6f2d63c799d68129300901eb0e962dd4.jpg, createdBy=ddf12178538, createdName=小贝熊, createdTime=Sun Apr 22 00:17:45 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 维他命

    #高血压患者#

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Mon Apr 23 08:03:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308406, encodeId=88cd30840610, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Mon Apr 23 06:53:11 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308286, encodeId=5df2308286a9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/27/6f2d63c799d68129300901eb0e962dd4.jpg, createdBy=ddf12178538, createdName=小贝熊, createdTime=Sun Apr 22 00:17:45 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-23 yfjms

    学习

    0

  8. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/27/6f2d63c799d68129300901eb0e962dd4.jpg, createdBy=ddf12178538, createdName=小贝熊, createdTime=Sun Apr 22 00:17:45 CST 2018, time=2018-04-22, status=1, ipAttribution=)]
    2018-04-22 惠映实验室

    学习了.谢谢分享.

    0

  9. 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    2018-04-22 溜溜梅不酸

    在高血压合并T2D患者中.蛋白尿的变化与肾脏风险的变化相关.

    0

  10. 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    2018-04-22 小贝熊

    学习学习学习

    0

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