Rheumatology:自体干细胞移植改善系统性硬化患者的心肺运动测试结果

2022-07-27 紫菀款冬 MedSci原创

评估自体造血干细胞移植(AHSCT)后系统性硬化症(SSc)患者的心肺功能结果。

目的:自体造血干细胞移植(AHSCT)是治疗严重系统性硬化症(SSc)患者的一种疾病改良疗法。该研究旨在评估AHSCT后SSc患者的心肺功能结果

方法:该回顾性研究包括27例接受AHSCT治疗的SSc成人患者。大多数患者有弥漫性皮肤亚群(93%)和肺部受累(85%)。在AHSCT前和12个月后,患者接受了心肺运动试验(CPET)经胸超声心动图一氧化碳扩散能力肺功能试验(DLCO)6分钟步行试验(6MWT)和生活质量评估

结果:与基线相比,AHSCT后,VO2峰值从954mL/min增加到1029 mL/min(p = 0.02),预测峰值VO2百分比从48.9m增加到53.5m(p = 0.01),6MWT测量的距离从445m增加到502m(p = 0.01)。VO2峰值的改善与6MWT距离的改善呈正相关,与静息心率的降低呈负相关。

在基线检查时,DLCO>70%的患者的VO2峰值高于DLCO<70%的患者(p = 0.04),但在AHSCT后,所有患者的VO2值都有所改善,而与基线DLCO水平无关。

AHSCT后,VO2水平的增加与SF-36生活质量问卷的身体成分分数的增加呈正相关 (r = 0.70, p = 0.0003)。

结论:AHSCT改善了SSc患者的有氧能力,这可能反映了肺、骨骼肌和心脏功能的综合增量

文献来源:

Gadioli LP, Costa-Pereira K, Dias JBE, et al. Autologous stem cell transplantation improves cardiopulmonary exercise testing outcomes in systemic sclerosis patients [published online ahead of print, 2022 Jul 21]. Rheumatology (Oxford). 2022;keac413. doi:10.1093/rheumatology/keac413

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