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Lancet Neurology：1例SARS-CoV-2感染后疑似引起帕金森病

2020-10-31 MedSci原创 MedSci原创

帕金森病，SARS-CoV-2感染，病毒
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帕金森氏病或帕金森综合征常在病毒感染后被描述，如：甲型流感病毒、爱泼斯坦-巴尔病毒、水痘带状疱疹病毒、丙型肝炎病毒、艾滋病毒、日本脑炎病毒或西尼罗病毒。

帕金森氏病或帕金森综合征常在病毒感染后被描述，如：甲型流感病毒、爱泼斯坦-巴尔病毒、水痘带状疱疹病毒、丙型肝炎病毒、艾滋病毒、日本脑炎病毒或西尼罗病毒。本文报告了一名患者可能患有帕金森氏症，他是在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后被确诊的。

2020年3月17日，一名45岁的犹太人因干咳和肌肉疼痛在Samson Assuta Ashdod University Hospital（Ashdod，Israel）住院治疗。入院前几天，他还注意到了自己嗅觉的丧失。他的症状开始于3月11日，也就是从一周的美国之旅返回以色列的两天后。他可能在返回以色列的航班上接触到了病毒，因为他回忆说坐在他身后的一名乘客反复咳嗽。他以前的病史包括高血压，每天服用200毫克拉贝洛尔、80毫克缬沙坦和5毫克氨氯地平。此外, 他还患有哮喘。在入院当天做鼻咽拭子后，通过实时RT-PCR检测，他被发现SARS-CoV-2呈阳性，全血计数及CRP测定正常。

在COVID 19病房住院期间，患者出现疲劳、气短和胸痛，但没有发烧。其作为住院患者接受了3天的治疗，主要是根据轻度哮喘症状的需要使用沙丁胺醇吸入剂，不需要全身药物治疗、补充氧气或机械通气。该患者随后于3月20日被隔离。随后，他在3月25日和3月30日做了鼻咽部拭子检查，结果呈阴性。然而，在3周的隔离期内，他注意到自己的笔迹已经变了，变得比以前更小、更不可读。他开始在手机上发短信很困难。他的右手也有阵发性颤抖。回到家后，他继续出现这些症状并最终被收治神经科。在检查时，患者出现语言障碍，颈部和右臂中度僵硬，左臂轻度僵硬，右肢中度运动迟缓，左肢轻度运动迟缓，无震颤。他的步态稍慢，没有右臂摆动，走路时肘部呈屈曲状态，但步幅和高度正常。拉力试验中没有发现向后收缩。脑部计算机断层扫描、磁共振成像上的弥散和液体衰减反转恢复序列以及脑电图都正常。但是PET扫描显示两个壳核的18F-FDOPA摄取减少，左侧更明显。

综上所述，帕金森病常伴有嗅觉缺失，这是SARS-CoV-2感染的一个常见特征。嗅觉系统的免疫激活可能最终导致α-突触核蛋白的错误折叠和帕金森病的进展。这一机制得到了尸检研究的支持，显示TNF、IL1和IL6水平升高。此外，与年龄相匹配的健康对照组相比，帕金森病患者对季节性冠状病毒的脑脊液抗体反应升高。

Cohen, Mikhal E et al. A case of probable Parkinson's disease after SARS-CoV-2 infection. The Lancet Neurology, Volume 19, Issue 10, 804 - 805

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    2022-06-26 屋顶瞄爱赏月

    签到学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1228779, encodeId=8b7c1228e7941, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jun 26 15:58:01 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937966, encodeId=5491193e966f4, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Jan 05 06:45:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830879, encodeId=9ada18308e9e2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 20 11:45:34 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001135, encodeId=bb1f2001135f8, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 09 05:45:34 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321232, encodeId=53461321232ae, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Nov 02 10:45:34 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895993, encodeId=bdc4895993d3, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道<a href='/topic/show?id=4e334851457' target=_blank style='color:#2F92EE;'>#帕金森氏病#</a>，<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>，<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>等, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 01 08:26:00 CST 2020, time=2020-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034024, encodeId=5b331034024b6, content=顶刊就是不一样，质量很高，内容精彩！学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Oct 31 22:45:34 CST 2020, time=2020-10-31, status=1, ipAttribution=)]
    2021-01-05 hukaixun

    #SARS-CoV#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1228779, encodeId=8b7c1228e7941, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jun 26 15:58:01 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937966, encodeId=5491193e966f4, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Jan 05 06:45:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830879, encodeId=9ada18308e9e2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 20 11:45:34 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001135, encodeId=bb1f2001135f8, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 09 05:45:34 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321232, encodeId=53461321232ae, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Nov 02 10:45:34 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895993, encodeId=bdc4895993d3, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道<a href='/topic/show?id=4e334851457' target=_blank style='color:#2F92EE;'>#帕金森氏病#</a>，<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>，<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>等, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 01 08:26:00 CST 2020, time=2020-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034024, encodeId=5b331034024b6, content=顶刊就是不一样，质量很高，内容精彩！学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Oct 31 22:45:34 CST 2020, time=2020-10-31, status=1, ipAttribution=)]
    2021-06-20 howi

    #Lancet#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1228779, encodeId=8b7c1228e7941, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jun 26 15:58:01 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937966, encodeId=5491193e966f4, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Jan 05 06:45:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830879, encodeId=9ada18308e9e2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 20 11:45:34 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001135, encodeId=bb1f2001135f8, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 09 05:45:34 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321232, encodeId=53461321232ae, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Nov 02 10:45:34 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895993, encodeId=bdc4895993d3, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道<a href='/topic/show?id=4e334851457' target=_blank style='color:#2F92EE;'>#帕金森氏病#</a>，<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>，<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>等, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 01 08:26:00 CST 2020, time=2020-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034024, encodeId=5b331034024b6, content=顶刊就是不一样，质量很高，内容精彩！学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Oct 31 22:45:34 CST 2020, time=2020-10-31, status=1, ipAttribution=)]
    2021-10-09 zhaojie88

    #Neurol#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1228779, encodeId=8b7c1228e7941, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jun 26 15:58:01 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937966, encodeId=5491193e966f4, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Jan 05 06:45:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830879, encodeId=9ada18308e9e2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 20 11:45:34 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001135, encodeId=bb1f2001135f8, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 09 05:45:34 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321232, encodeId=53461321232ae, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Nov 02 10:45:34 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895993, encodeId=bdc4895993d3, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道<a href='/topic/show?id=4e334851457' target=_blank style='color:#2F92EE;'>#帕金森氏病#</a>，<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>，<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>等, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 01 08:26:00 CST 2020, time=2020-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034024, encodeId=5b331034024b6, content=顶刊就是不一样，质量很高，内容精彩！学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Oct 31 22:45:34 CST 2020, time=2020-10-31, status=1, ipAttribution=)]
    2020-11-02 小刀医生

    #SARS#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1228779, encodeId=8b7c1228e7941, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jun 26 15:58:01 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937966, encodeId=5491193e966f4, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Jan 05 06:45:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830879, encodeId=9ada18308e9e2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 20 11:45:34 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001135, encodeId=bb1f2001135f8, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 09 05:45:34 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321232, encodeId=53461321232ae, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Nov 02 10:45:34 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895993, encodeId=bdc4895993d3, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道<a href='/topic/show?id=4e334851457' target=_blank style='color:#2F92EE;'>#帕金森氏病#</a>，<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>，<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>等, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 01 08:26:00 CST 2020, time=2020-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034024, encodeId=5b331034024b6, content=顶刊就是不一样，质量很高，内容精彩！学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Oct 31 22:45:34 CST 2020, time=2020-10-31, status=1, ipAttribution=)]
    2020-11-01 lovetcm

    #新冠肺炎#实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道#帕金森氏病#，#卒中#，#多系统炎症综合征#等

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1228779, encodeId=8b7c1228e7941, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Sun Jun 26 15:58:01 CST 2022, time=2022-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1937966, encodeId=5491193e966f4, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Jan 05 06:45:34 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830879, encodeId=9ada18308e9e2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Jun 20 11:45:34 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001135, encodeId=bb1f2001135f8, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Oct 09 05:45:34 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321232, encodeId=53461321232ae, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Nov 02 10:45:34 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895993, encodeId=bdc4895993d3, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>实际上病毒本身并不可怕，可怕的是血管内皮损伤的不确定性，可能由此引发血栓，以及器官的供血损伤，从而引发各个器官或组织的损害，包括有报道<a href='/topic/show?id=4e334851457' target=_blank style='color:#2F92EE;'>#帕金森氏病#</a>，<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>，<a href='/topic/show?id=cfae433e3a4' target=_blank style='color:#2F92EE;'>#多系统炎症综合征#</a>等, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中), TopicDto(id=43373, encryptionId=cfae433e3a4, topicName=多系统炎症综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 01 08:26:00 CST 2020, time=2020-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034024, encodeId=5b331034024b6, content=顶刊就是不一样，质量很高，内容精彩！学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Oct 31 22:45:34 CST 2020, time=2020-10-31, status=1, ipAttribution=)]
    2020-10-31 goodbing

    顶刊就是不一样，质量很高，内容精彩！学到很多

    0