J Dent Res:饮食所诱导的肥胖及饮食差异对牙槽骨丧失的影响

2015-10-11 sunshine 译 MedSci原创

J Dent Res:饮食所诱导的肥胖及饮食差异对牙槽骨丧失的影响肥胖与血脂代谢异常以及骨代谢异常有关。本研究旨在探究特定脂肪酸(FA)水平的升高对牙龈卟啉单胞菌所诱导的牙周病模型中骨丧失的影响,并以此来分析小鼠模型中破骨细胞吸收骨和成骨细胞成骨的细胞机制。研究选用了四周龄的雄性C57BL/6小鼠,随机分为三组,A组小鼠喂以含棕榈酸(PA)的高脂肪食物(HFD),B组小鼠喂以富含油酸(OA)的高脂

肥胖与血脂代谢异常以及骨代谢异常有关。本研究旨在探究特定脂肪酸(FA)水平的升高对牙龈卟啉单胞菌所诱导的牙周病模型中牙槽骨骨质疏松的影响,并以此来分析小鼠模型中破骨细胞的骨吸收和骨细胞的骨形成的细胞机制。

研究选用了四周龄的雄性C57BL/6小鼠,随机分为三组,A组小鼠喂以含棕榈酸(PA)的高脂肪食物(HFD),B组小鼠喂以富含油酸(OA)的高脂肪食物(从FA中获得20%的热量),C组小鼠喂以正常热量的食物(从FA中获得10%的热量),饲养16周。从第十周开始,使用牙龈卟啉单胞菌(W50)或安慰剂感染小鼠的牙周组织以诱导小鼠牙周组织的骨质流失。16周后处死小鼠,测量小鼠的脂肪比重、血清炎症(肿瘤坏死因子TNF-α)、骨代谢(骨钙素OC)、羟基端胶原交联(CTX)以及I型胶原N端前肽(P1NP)标志物。分别在高水平的PA及OA环境中培养成骨细胞和破骨细胞,并暴露于牙龈卟啉单胞菌中。

结果发现,与正常饮食组小鼠相比,富含FA饮食的小鼠体重明显要高(P < 0.05)。A组与B组肥胖小鼠的脂肪比重相似(P = nonsignificant);但是,A组小鼠的牙槽骨骨质疏松程度明显更高一些(P < 0.05)。A组小鼠TNF-α的水平在三组中最高(P < 0.001),暴露于牙龈卟啉单胞菌中后,三组小鼠的TNF-α水平均有所升高(P < 0.01),此外,A组小鼠中骨重建的标志物OC、CTX以及P1NP的水平却是三组中最低的(P < 0.001),而C组却是三组中最高的。暴露于牙龈卟啉单胞菌中后,三组小鼠的骨代谢标志物的水平均有所降低(P < 0.01)。同样暴露于牙龈卟啉单胞菌中,暴露于PA环境中破骨细胞的炎症反应较暴露于OA环境中的破骨细胞的炎症反应要强一些,而暴露于OA中的破骨细胞的炎症反应与对照组的破骨细胞炎症反应类似。

这些发现表明,调节骨代谢以影响牙槽骨的骨质疏松的是饮食中特定的脂肪酸结构而非仅仅是体重增加或机体肥胖。

原始出处:

Muluke M, Gold T et al.Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss. J Dent Res. 2015 Oct 8. pii: 0022034515609882.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-01-21 mei543
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    2016-02-10 mei540
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    2015-12-22 xiaotaiyang1

    又是肥胖

    0

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众所周知,脂肪酸(FAs)对于胎儿生长发育至关重要,尤其是长链多不饱和脂肪酸。而先前有研究表明暴露于全氟化物(PFCs)会打破脂肪酸的体内平衡,但是目前并没有关于全氟化物暴露对脂肪酸影响的流行病学数据。因此Kishi R等人进行了一项研究,以调查妊娠期全氟辛烷磺酸(PFOS)/全氟辛酸(PFOA)暴露对孕妇体内脂肪酸(FAs)水平、体内甘油三酯(TG)水平、以及新生儿出生体重的影响。

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血浆磷脂饱和脂肪酸(phospholipid saturated fatty acids,SFA)与糖尿病的关系一直并不清楚。最新一项研究发表在Lancet子刊上,认为二者密切关联。该 研究来自于著名的病例队列研究EPIC-InterAct。该研究共纳入12403位发生2型糖尿病的患者,以及从340234欧洲群体中选择的代表性亚 队列16154人进行对照研究。SFA采用气相色谱法进行检测。亚队

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简介:炎症对前列腺癌发挥着病原学的作用。几个饮食因素影响炎症;研究表明,长链的n - 3多元不饱和脂肪酸是抗炎的,而n-6和反式脂肪酸是促炎的。方法:我们评估血清磷脂的n-3、n-6和反式脂肪酸与前列腺内炎症是否有关联,前列腺癌的预防试验(PCPT)包括191例前列腺癌病例和247例安慰剂对照组。没有接受前列腺癌诊断的男性在试验结束后进行前列腺活检,良性前列腺组织炎症在每个男性