ACG 2015:糖尿病+高血压会导致肝癌风险增加4倍!

2015-10-25 MedSci MedSci原创

一项回顾性研究表明,糖尿病和高血压是肝细胞癌的独立危险因子,就算患者有没有肝硬化或是导致肝硬化的高危因素。那么这个结果是不是就以为着需要对没有肝硬化的糖尿病和高血压患者进行肝细胞癌的筛查呢?这样做性价比会高吗?先前也有研究表明糖尿病会增加肝细胞癌风险,其他代谢相关疾病如高血压高血脂同样会导致其风险增加。该回顾性研究纳入了2008-2012年间17446名肝细胞癌患者。排除混杂因素如肝硬化、HBV感

一项回顾性研究表明,糖尿病高血压是肝细胞癌的独立危险因子,就算患者有没有肝硬化或是导致肝硬化的高危因素。

那么这个结果是不是就以为着需要对没有肝硬化的糖尿病高血压患者进行肝细胞癌的筛查呢?这样做性价比会高吗?

先前也有研究表明糖尿病会增加肝细胞癌风险,其他代谢相关疾病如高血压高血脂同样会导致其风险增加。

该回顾性研究纳入了2008-2012年间17446名肝细胞癌患者。排除混杂因素如肝硬化、HBV感染、酒精性肝损伤、脂肪肝等最终队列包括7473名患者。按1:3根绝年龄、性别等匹配了22110名对照组。

研究结果显示糖尿病会增加肝细胞癌风险 (OR, 1.353),增加高血压风险 (OR, 1.229) ,增加丙肝风险 (OR, 2.102)。相反,高血脂却可以对肝细胞癌起保护作用(OR, 0.885)。

对于糖尿病的治疗如胰岛素,会增加肝细胞癌风险 (OR, 1.640),但是二甲双胍却起保护作用 (OR, 0.706)。

当患者有糖尿病+高血压+丙肝时,其发生肝细胞癌风险增加4倍(OR, 4.580),当然只有糖尿病+高血压,该风险也是非常高(OR, 3.399)。加入高脂血症则风险为2倍左右:糖尿病+高脂血症+丙肝(OR, 2.319),糖尿病+高脂血症 (OR, 2.395)。

该项回顾性研究的参与者相对较年轻,年龄在16-64岁,因此可能会对低估了一些因素的作用。并且该研究并没有分析肥胖对肝细胞癌的影响,众所周知肥胖也是很关键的因素之一。

原始出处:

American College of Gastroenterology (ACG) 2015 Annual Meeting: Abstract 1. Presented October 19, 2015.

Medscape:Diabetes, Hypertension Raise Risk for Liver Cancer

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    2015-12-28 wzf990214

    有意思

    0

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    2015-12-28 wzf990214

    不错哦

    0

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    2015-12-28 wzf990214

    赞一个

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1685515, encodeId=b60c16855152e, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Tue Mar 01 00:23:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49818, encodeId=308349818df, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49819, encodeId=5550498193c, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49820, encodeId=56334982049, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061485, encodeId=1c702061485ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 07 18:23:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43253, encodeId=dc7e43253ce, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Nov 15 23:57:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41297, encodeId=03e24129ed5, content=不知道目前此类研究多不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Oct 26 09:05:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41287, encodeId=399b4128e4c, content=有价值是的回顾。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Mon Oct 26 08:20:00 CST 2015, time=2015-10-26, status=1, ipAttribution=)]
    2015-11-07 sjq027
  6. [GetPortalCommentsPageByObjectIdResponse(id=1685515, encodeId=b60c16855152e, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Tue Mar 01 00:23:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49818, encodeId=308349818df, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49819, encodeId=5550498193c, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49820, encodeId=56334982049, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061485, encodeId=1c702061485ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 07 18:23:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43253, encodeId=dc7e43253ce, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Nov 15 23:57:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41297, encodeId=03e24129ed5, content=不知道目前此类研究多不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Oct 26 09:05:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41287, encodeId=399b4128e4c, content=有价值是的回顾。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Mon Oct 26 08:20:00 CST 2015, time=2015-10-26, status=1, ipAttribution=)]
    2015-11-15 lecoo

    长知识

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1685515, encodeId=b60c16855152e, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Tue Mar 01 00:23:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49818, encodeId=308349818df, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49819, encodeId=5550498193c, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49820, encodeId=56334982049, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061485, encodeId=1c702061485ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 07 18:23:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43253, encodeId=dc7e43253ce, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Nov 15 23:57:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41297, encodeId=03e24129ed5, content=不知道目前此类研究多不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Oct 26 09:05:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41287, encodeId=399b4128e4c, content=有价值是的回顾。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Mon Oct 26 08:20:00 CST 2015, time=2015-10-26, status=1, ipAttribution=)]
    2015-10-26 huangwukui

    不知道目前此类研究多不多

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1685515, encodeId=b60c16855152e, content=<a href='/topic/show?id=33ec184597' target=_blank style='color:#2F92EE;'>#ACG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1845, encryptionId=33ec184597, topicName=ACG)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a63228213450, createdName=1249842em18(暂无昵称), createdTime=Tue Mar 01 00:23:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49818, encodeId=308349818df, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49819, encodeId=5550498193c, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49820, encodeId=56334982049, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:27:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061485, encodeId=1c702061485ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 07 18:23:00 CST 2015, time=2015-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43253, encodeId=dc7e43253ce, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Sun Nov 15 23:57:00 CST 2015, time=2015-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41297, encodeId=03e24129ed5, content=不知道目前此类研究多不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Oct 26 09:05:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41287, encodeId=399b4128e4c, content=有价值是的回顾。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Mon Oct 26 08:20:00 CST 2015, time=2015-10-26, status=1, ipAttribution=)]
    2015-10-26 gzhjjx

    有价值是的回顾。

    0

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