Br J Cancer:多吃水果和蔬菜能降低乳腺癌患病风险

2021-05-23 xiaozeng MedSci原创

乳腺癌作为全球女性中最常见的癌症,也是癌症相关死亡的主要原因之一。

乳腺癌作为全球女性中最常见的癌症,也是癌症相关死亡的主要原因之一。然而,全球乳腺癌的发病率差异很大,这也可能部分反映了不同生活方式之间的差异因素。

既往的大规模公共卫生措施和临床干预措施揭示,可改变的生活方式风险因素可降低乳腺癌的患病风险。饮食的组成是一种可以降低乳腺癌发病率的潜在生活方式因素。


水果和蔬菜含有大量潜在的抗癌营养素和生物活性物质,可以降低罹患癌症的风险。然而,目前的流行病学评估水果和蔬菜摄入量对乳腺癌患病风险的影响研究并不一致。

该前瞻性研究旨在通过系统性回顾和荟萃分析,以阐明食用水果和蔬菜与乳腺癌的相关性。


该前瞻性研究通过系统搜索纳入了截至2020年11月的PubMed和EMBASE数据库的相关研究数据,这些研究报告了水果和蔬菜的摄入量与乳腺癌的相关性。

研究流程图

研究人员计算了相对于母乳的最高和最低类别的水果和蔬菜总量、水果和蔬菜的总消费量以及果汁和蔬菜亚组的汇总相对风险(RRs)和癌症发病率。


结果显示,较高的水果和蔬菜的总摄入量与较低的总体和绝经后乳腺癌患病风险相关。较高的水果摄入总量与较低的总体和绝经后乳腺癌患病风险相关。高水果和蔬菜的总摄入量分别使雌激素受体和孕激素受体阳性(ER +/PR+)和阴性(ER-/PR-)乳腺癌的患病风险分别降低11%和26%。

蔬果总摄入量与乳腺癌风险的关系

而较高的蔬菜总摄入量对应着ER-/PR-乳腺癌风险降低27%。果汁的饮用与总体乳腺癌风险相关。然而并没有发现蔬菜摄入量与乳腺癌风险之间存在显著相关性。


总而言之,该研究结果揭示,较高的水果和蔬菜总摄入量与总体以及绝经后ER+/PR+和ER-/PR-乳腺癌较低的患病风险相关。


原始出处:

Farvid, M.S., Barnett, J.B. & Spence, N.D. Fruit and vegetable consumption and incident breast cancer: a systematic review and meta-analysis of prospective studies. Br J Cancer (18 May 2021).

 

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    2021-07-16 ms6000001661372787

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    2021-05-24 ms2000001361349190

    应季水果

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    2021-05-23 汉水人家

    学习学习

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    2021-05-23 ms2000001051330459

    学习了,涨知识了!

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    2021-05-23 ZANXT

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Am J Clin Nutr:乳制品和钙的摄入量与乳腺癌风险的相关性

酸奶和干酪/乳清奶酪与乳腺癌风险的相关性因ER状态而存在差异,其与ER阴性乳腺癌存在一定相关性

Br J Cancer:绝经前后激素水平与浸润性乳腺癌的发病风险相关

乳腺癌作为全球女性中最常见的癌症之一,其是激素依赖性的。

Nat Commun:细胞外泌体(EVs)蛋白质分析:转移性乳腺癌患者治疗反应的潜在监测指标

转移性乳腺癌(MBC)是一种包括多种不同亚型的异质性疾病,其是全球女性癌症死亡的主要原因之一。

JAMA Surgery:对社会经济、伴随疾病因素调整后,乳腺癌患者保乳术和乳房切除术的生存比较:来自瑞典48986例女性乳腺癌患者超6年随访结果

尽管对很多因素进行了调整,乳腺保乳术(BCS)联合放疗(RT)仍较乳房切除术(Mx)使患者获得生存获益,不管后者是否联合RT。因此,对于同等条件下,MX不应该视等同于BCS。

2021BOC/BOA:殷咏梅教授解读CDK4/6抑制剂阿贝西利中国临床实践数据,以期提高可及性

2021年7月2~3日,中国临床肿瘤学会(CSCO)联合北京市希思科临床肿瘤学研究基金会共同主办的“2021年中国临床肿瘤学年度进展研讨会(BOC)暨Best of ASCO® 2021 China”