Neurology:1000万人的荟萃分析发现,癌症患者更容易得脑中风

2020-12-22 蔡梦飞 MedSci原创

Neurology | 1000万人的荟萃分析发现,癌症患者更容易得脑中风

Neurology | 1000万人的荟萃分析发现,癌症患者更容易得脑中风
 
癌症和中风是导致死亡和残疾的两个主要原因,也是全球主要的公共卫生问题。它们具有高度重叠的危险因素(如糖尿病、高血压、肥胖症、高脂血症和生活方式因素),并具有相似的发生机制。
 
越来越多的证据表明,癌症幸存者患心脑血管疾病(包括中风、冠状动脉疾病和心力衰竭)的风险和死亡率高于一般人群。
近几十年来,癌症的筛查诊断和治疗技术取得了前所未有的进展,相当数量的癌症患者在标准化治疗后可以存活超过5年。然而,癌症存活者中风和死亡的风险比非癌症人口增加。这可能是由于癌症治疗(化疗或放疗)导致的高凝状态或并发症。
 
目前缺乏大规模的队列试验去探究癌症幸存者的脑卒中风险。一些研究表明,具有特定癌症类型的患者比非癌症对照组有更高的中风风险,比如,血液系统癌症、胰腺癌、鼻咽癌、肺癌、头颈部癌和甲状腺癌。然而,其他研究发现,癌症幸存者可能有较低的中风风险,如宫颈癌。这些相互矛盾的研究在需要我们系统、全面评估癌症和随后的中风风险之间的关系。
 
上海曙光医院团队,近日发表在Neurology上的Meta分析囊括了20个人群研究的1000万人数据,系统分析了癌症和脑卒中的关系。
 
总的来说,与非癌症对照组相比,癌症(头颈部、血液学、肺部、胰腺,胃部肿瘤,)存活者中风的 RR 为1.66 ,
胃癌(均 p < 0.05)显示出一致的结果,而其他类型的癌症风险没有显著增加。对女性癌症存活者的影响更为显著(RR =1.38) ,确诊时年龄小于45岁 (RR = 2.57)和较短的生存期(≥1ー2年)(RR = 1.69)。
 
与出血性卒中相比,癌症存活者缺血性卒中的风险明显增加(RR =1.53)。
 
这项研究的重要意义在于:再次系统深入探究并证明了肿瘤在脑卒中的病因学中有着重要作用。但因为所纳入的研究队列之间存在着很大的异质性,所以对于文章的meta分析结果需要更加审慎对待,在癌症幸存者中,对中风进行早期预防和有效干预仍然需要卫生政策制定的积极参与。
 
参考文献
 
 
 
 

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  2. 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    2021-09-01 venlin
  3. 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    2021-05-14 yinhl1978
  4. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20d91529085, createdName=wj1301859, createdTime=Tue Dec 22 08:24:24 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909948, encodeId=25c29099481f, content=1000万人的荟萃分析发现,癌症患者更容易得脑中风, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Tue Dec 22 07:36:44 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045996, encodeId=8ef6104599651, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 22 03:18:25 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-23 三生有幸9135

    癌症和中风是导致死亡和残疾的两个主要原因,也是全球主要的公共卫生问题。它们具有高度重叠的危险因素(如糖尿病、高血压、肥胖症、高脂血症和生活方式因素),并具有相似的发生机制

    0

  5. 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  6. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20d91529085, createdName=wj1301859, createdTime=Tue Dec 22 08:24:24 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909948, encodeId=25c29099481f, content=1000万人的荟萃分析发现,癌症患者更容易得脑中风, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Tue Dec 22 07:36:44 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045996, encodeId=8ef6104599651, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 22 03:18:25 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 慎独

    癌症患者高凝状态?

    3

    展开3条回复
  7. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20d91529085, createdName=wj1301859, createdTime=Tue Dec 22 08:24:24 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909948, encodeId=25c29099481f, content=1000万人的荟萃分析发现,癌症患者更容易得脑中风, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Tue Dec 22 07:36:44 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045996, encodeId=8ef6104599651, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 22 03:18:25 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 刘晓捷

    特别多对对对你你你

    0

  8. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20d91529085, createdName=wj1301859, createdTime=Tue Dec 22 08:24:24 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909948, encodeId=25c29099481f, content=1000万人的荟萃分析发现,癌症患者更容易得脑中风, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Tue Dec 22 07:36:44 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045996, encodeId=8ef6104599651, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 22 03:18:25 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 wj1301859

    有用

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 22 03:18:25 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 Lizhihua6

    1000万人的荟萃分析发现,癌症患者更容易得脑中风

    0

  10. 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level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20d91529085, createdName=wj1301859, createdTime=Tue Dec 22 08:24:24 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=909948, encodeId=25c29099481f, content=1000万人的荟萃分析发现,癌症患者更容易得脑中风, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/58e01f5adcbf4aae90dfc25bd03c739f/1aca8d53476d43fca347e4819bda61f4.jpg, createdBy=b2d85436799, createdName=Lizhihua6, createdTime=Tue Dec 22 07:36:44 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045996, encodeId=8ef6104599651, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Tue Dec 22 03:18:25 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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